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Clinical Trial Summary

Chronic Kidney Disease (CKD) induces many metabolic troubles especially for the advanced CKD (stage 3b-5) patients and their prevalence and importance grow with the deterioration of the glomerular filtration rate (GFR). Among them, muscle wasting is common and multifactorial, partially explained by an imbalance between protein catabolism and synthesis. Muscular strength is also affected beyond the reduction of the lean body mass, resulting in profound fatigue. The present study seeks to quantify the prevalence of low muscular strength production (dynapenia) in a cohort of elderly patients with advanced CKD, through a maximal voluntary contraction (MVC) handgrip test compared to control data available in the literature, matched in term of age and sex. It also aims to investigate the link between the reported fatigue (subjective) and the evolution of the MVC, called critical force (fcrit) during a fatiguing task (objective fatigability).


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT04330807
Study type Interventional
Source Centre Hospitalier le Mans
Contact Christelle JADEAU
Phone 0033 2 43 43 43 43
Email cjadeau@ch-lemans.fr
Status Recruiting
Phase N/A
Start date June 22, 2020
Completion date June 2022

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