Chronic Hepatitis C Clinical Trial
Official title:
Ribavirin Dose Optimization for the Treatment of Hepatitis C: A Pilot Study
Patients for whom treatment with peginterferon plus ribavirin was unsuccessful represent a
category of patients for whom there is currently no worthwhile therapeutic alternative.
Several studies have shown that there is a relation between plasma ribavirin concentrations
and treatment response. Adequate ribavirin plasma concentrations, especially during the
first 12 weeks of treatment, should be associated with a better chance of response to the
treatment.
The strategy for this study will be to use a loading dose of ribavirin before beginning the
treatment with peg-interferon, thereby allowing for optimal ribavirin concentrations to be
reached, and possibly improving the effectiveness of the treatment.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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