Effects of Genotypes on Interferon Signaling in Chronic Hepatitis C

Status Withdrawn

Clinical Trial Summary

The objective of this pilot project is to investigate the prognostic criteria for sensitivity of Chronic Hepatitis C (CHC) Genotype 1, patients to IFNa treatment. Signal transduction in peripheral blood mononuclear cell (PBMC) of control groups will be compared with that of CHC patients. For this study, 20 patients with Hepatitis C virus (HCV) infection who are to undergo standard antiviral therapy and 10 healthy donors (significant others of the HCV subject) will be enrolled. Signal transduction will be studied in peripheral blood of CHC subjects before the treatment, after 1 and 3 months of treatment, and 4-6 months following the completion of treatment.

Clinical Trial Description

In addition, the mechanism of non-responsiveness of HCV patients to IFNa will be studied. For this purpose, formation of complexes between STAT1 and its negative regulator, PIAS1 (immunoprecipitation, Western blot) will be examined. In comparing subjects on standard therapy vs the addition of betaine, (under separate studies) we will assess whether the formation of STAT1-PIAS1 complexes is due to impaired methylation on STAT1 on arginine residues which may be over come by the addition of betaine. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00876174
Study type	Observational
Source	University of Nebraska
Contact
Status	Withdrawn
Phase
Start date	April 15, 2009
Completion date	January 8, 2010

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01937975` - The Pharmacokinetics of Grazoprevir (MK-5172) and Elbasvir (MK-8742) in Participants With Renal Insufficiency (MK-5172-050)	Phase 1
Completed	`NCT03673696` - The Tolerability and Pharmacokinetics Study of HEC74647PA Capsule in Healthy Adult Subjects	Phase 1
Completed	`NCT02250001` - Asunaprevir/Daclatasvir Safety Surveillance in Japanese Patients With Chronic Hepatitis C	N/A
Completed	`NCT03088917` - 'Fibrosis in the Lost Hepatitis C Population - Track, Trace and Treat'
Completed	`NCT02207088` - Ombitasvir/ABT-450/Ritonavir and Dasabuvir With or Without Ribavirin in HCV Genotype 1-Infected Adults With Chronic Kidney Disease	Phase 3
Not yet recruiting	`NCT02865369` - Regression of Liver Fibrosis After Daclatasvir and Asunaprevir Treatment	N/A
Recruiting	`NCT02638233` - Therapy With Ledipasvir/Sofosbuvir in Patients With Genotype 1 HCV Infection Receiving Opiate Substitution Therapy	Phase 4
Not yet recruiting	`NCT02511496` - Status of Chronic Liver Disease in Hepatitis C Virus (HCV) Patients Coinfected With Human Immunodeficiency Virus (HIV) in Andalusia	N/A
Not yet recruiting	`NCT01949168` - A Pilot Study of Boceprevir for the Treatment of Genotype 6 HCV	Phase 2
Completed	`NCT02788682` - Association of Vitamin D Binding Protein Polymorphisms With Response to HCV Therapy	N/A
Completed	`NCT01439776` - Add Vitamin D With Standard of Care for Chronic Hepatitis C Patients	Phase 4
Recruiting	`NCT01360879` - Assessment of Liver FIBROsis by Real-time Tissue ELASTography in Chronic Liver Disease	N/A
Recruiting	`NCT01360892` - Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography	N/A
Completed	`NCT00968357` - Proof-of-concept Study to Evaluate the Safety and Immunomodulatory Effects of SCV 07 as Monotherapy or in Combination With Ribavirin in Noncirrhotic Subjects With Chronic Hepatitis C Who Have Relapsed	Phase 2
Terminated	`NCT00962936` - Safety and Tolerability Study of the Monoclonal Antibody CT-011 in Patients With Chronic Hepatitis C Genotype I Infection	Phase 1/Phase 2
Recruiting	`NCT00575627` - Pegylated-Interferon and Ribavirin in Hepatitis C Patients With Persistently Normal Alanine Aminotransferase Levels	Phase 4
Recruiting	`NCT01178749` - Exploration of Chronic Hepatitis C Infection Receiving 24-week Interferon-α With Ribavirin Treatments	N/A
Completed	`NCT00537407` - A Study of Debio 025 in Combination With PegIFN Alpha-2a and Ribavirin in Chronic HCV Patients Non-responders to Standard Treatment	Phase 2
Recruiting	`NCT00370617` - Pegylated-Interferon and Ribavirin Plus Metformin in the Treatment of Chronic HCV Infection and Insulin Resistance	Phase 4
Completed	`NCT01684787` - Study to Evaluate the Treatment for Chronic Hepatitis C With Normal Transaminases in HIV Positive Patients	Phase 4