The Establishment of Korean Hepatitis B Patients Cohort

Status Recruiting

Clinical Trial Summary

According to the World Health Organization about 1,400,000 deaths reported annually, are related to chronic liver disease. Chronic liver disease is very prevalent in South Korea, placing a large economic burden nationwide. Subsequently, an effective and systematized approach to managing chronic hepatitis is imperative in Korea.

The natural history of chronic liver disease differs greatly according to race and ethnicity. However, there is scarcity of epidemic data on chronic hepatitis based on Korean patients. Therefore, the investigators plan to establish a prospective multicenter cohort for chronic hepatitis B based on Korean patients that may be utilized for various future clinical studies on chronic hepatitis B in Korea, and thereby serve as a basis for the establishment and distribution of clinical guidelines for Korean patients with chronic hepatitis B, as part of a nationwide project supported by the Centers for Disease Control (CDC), Korea.

The investigators plan to collect more than 2,000 cases per year with 6 months of regular follow-up interval as have been advised by the CDC during 10 years of the study period (from Sep. 2015) from 5 tertiary hospitals located in Korea. The investigators plan to register available cases from those who are available to agree to give written informed consent and provide their blood samples to participate in this study prospectively, according to the inclusion and exclusion criteria.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04139850
Study type	Observational [Patient Registry]
Source	Yonsei University
Contact	Sang Hoon Ahn
Phone	+82-2-2228-1936
Email	ahnsh@yuhs.ac
Status	Recruiting
Phase
Start date	September 25, 2015
Completion date	August 2026

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04496882` - Chronic Hepatitis b Patients Switch to tAf After Discontinuation of Nucleoside Analogue	Phase 4
Completed	`NCT04083716` - A Study to Assess the Relative Bioavailability and Food Effect of ABI-H2158 in Healthy Adults	Phase 1
Not yet recruiting	`NCT03038802` - A Randomised Controlled Phase 1 Study of Vaccine Therapy for Control or Cure of Chronic Hepatitis B Virus Infection	Phase 1/Phase 2
Completed	`NCT05310487` - Phase 1 Study of 162, a Novel Neutralizing Antibody Targeting Hepatitis B Surface Antigen, in Healthy Adult Subjects	Phase 1
Recruiting	`NCT06070051` - Dose-Escalation Prime/Boost Therapeutic Vaccination Study Of 2 Chimp Adenoviral Vectors in Adults With Chronic HBV On Nucleos(t)Ide Therapy	Phase 1
Terminated	`NCT05001022` - A Study of ALG-020572 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single Doses in Healthy Volunteers and Multiple Doses in CHB Subjects	Phase 1
Recruiting	`NCT05343481` - Efficacy of VTP-300 in Chronic Hepatitis B Infection	Phase 2
Not yet recruiting	`NCT05490836` - Functional Cure Rate of Peg-IFNα-2b Combined With TAF in HBeAg Negative CHB Patients	N/A
Recruiting	`NCT04543565` - Pradefovir Treatment for the Patients With Chronic Hepatitis B Virus Infections: a Phase3 Study	Phase 3
Active, not recruiting	`NCT02894918` - A Study to Evaluate Addition of Peginterferon Alfa-2a to Chronic Hepatitis B (CHB) Patients Treated With NAs	Phase 4
Not yet recruiting	`NCT02793791` - Prophylactic Treatment of Hepatic Dysplastic Nodules in HBsAg Positive Patients	N/A
Recruiting	`NCT02287857` - Efficacy and Safety of Domestic Tenofovir Tablets in Chinese Patients With Chronic Hepatitis B	N/A
Recruiting	`NCT01965418` - A Clinical Evaluation on Traditional Chinese Medicine Diagnosis and Treatment Program Blocking and Reversing Hepatitis B-related Liver Fibrosis - a Randomized, Controlled, Double-blind, Multi-center Clinical Trial	Phase 4
Recruiting	`NCT01491295` - Switch to Tenofovir Versus Continue Lamivudine/Adefovir Treatment in Lamivudine-resistance Chronic Hepatitis B Patients	Phase 4
Terminated	`NCT01872988` - Tenofovir Antiviral Therapy Following Transarterial Chemoembolization for HBV Related Hepatocellular Carcinoma	Phase 3
Recruiting	`NCT01487876` - Efficacy and Safety of Dual-plasmid Hepatitis B Virus DNA Vaccine in Chronic Hepatitis B Patients	Phase 2
Completed	`NCT01531166` - A Cohort Study in Korean Patients With Chronic Hepatitis B (CHB) Receiving Pegylated Interferon	N/A
Not yet recruiting	`NCT01436539` - Study of Effects and Safety Between Adefovir Dipivoxil Plus Polyene Phosphatidylcholine Versus Adefovir Dipivoxil Alone in Chronic Hepatitis B Patients	Phase 4
Recruiting	`NCT01360879` - Assessment of Liver FIBROsis by Real-time Tissue ELASTography in Chronic Liver Disease	N/A
Recruiting	`NCT01360892` - Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography	N/A