Chronic Hepatitis B Clinical Trial
According to the World Health Organization about 1,400,000 deaths reported annually, are
related to chronic liver disease. Chronic liver disease is very prevalent in South Korea,
placing a large economic burden nationwide. Subsequently, an effective and systematized
approach to managing chronic hepatitis is imperative in Korea.
The natural history of chronic liver disease differs greatly according to race and
ethnicity. However, there is scarcity of epidemic data on chronic hepatitis based on Korean
patients. Therefore, the investigators plan to establish a retrospective and prospective
multicenter cohort for chronic hepatitis B based on Korean patients that may be utilized for
various future clinical studies on chronic hepatitis B in Korea, and thereby serve as a
basis for the establishment and distribution of clinical guidelines for Korean patients with
chronic hepatitis B, as part of a nationwide project supported by the Centers for Disease
Control (CDC), Korea.
The investigators plan to collect 500 cases as have been advised by the CDC during the study
period (September, 2014-March, 2015) from 4 tertiary hospitals located in Korea. In the past
5 years, there have been about 800 subjects with chronic hepatitis B who have undergone
liver fibroscan and liver biopsy from these 4 institutions. The investigators plan to
register available cases retrospectively from those who are available to agree to give
written informed consent to participate in this study, and to register the remaining numbers
of cases prospectively, according to the inclusion and exclusion criteria.
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