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Clinical Trial Summary

Treatment with a nucleoside analogue and subsequent viral decline has shown to partially restore immune hyporesponsiveness in chronic hepatitis B patients. Recent pilot studies investigating whether the effect of lowering viral load with nucleoside analogue therapy prior to the initiation of peginterferon results in higher sustained off-treatment responses showed contradictory findings.

The aim of this study is to investigate sustained off-treatment response to peginterferon alfa-2b in chronic HBeAg-positive hepatitis B patients who are pretreated with nucleos(t)ide analogues, thereby lowering viral load


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01532843
Study type Interventional
Source Foundation for Liver Research
Contact
Status Completed
Phase Phase 4
Start date June 2012
Completion date August 2015

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