Chronic Hepatitis B Clinical Trial
Official title:
A Prospective, Randomised, Open-label Phase IIb Clinical Trial Assessing the Effect of Pegylated Interferon Alfa-2a (Pegasys®)180 μg Once Weekly for 48 Weeks in Addition to an Ongoing Nucelos(t)Ide Based Treatment on Quantitative HBsAg Levels in Patients With Chronic HBeAg-negative Hepatitis B
A prospective, randomised, open-label phase IIb clinical trial assessing the effect of
pegylated interferon alfa-2a(Pegasys®) 180 μg once weekly for 48 weeks added to an ongoing
nucleos(t)ide based treatment in patients with chronic HBeAg-negative hepatitis B
The primary objective of the trial is to investigate whether the add-on of pegylated
interferon alfa-2a to a continued treatment with nucleos(t)ide analogues increases the
percentage of patients who have significant decrease (≥ 1log10) of HBs antigen after 48
weeks.
170 Patients with chronic hepatitis B, HBe antigen negative, already being treated with an
oral antiviral regimen and having a nondetectable viral load for at least 12 months are
included.
n/a
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