Chronic Hepatitis B Clinical Trial
Official title:
Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes, Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a
Serum HBV DNA is a referent but insufficient marker of therapeutic follow-up in chronic
hepatitis B treatment. Intra hepatic cccDNA disappearance reflects HBV eradication in the
liver.
Intra lymphocyte cccDNA could be a new marker of HBV eradication after treatment.
The major interest of this marker is that it can be measured by a simple blood test instead
of a liver biopsy.
- Studying intra lymphocyte and blood cccDNA: before inclusions, D0 then each month during
the first three months each three months during treatment and follow-up.
- Viral kinetics:Before inclusions, at D0, then monthly till the end of treatment and
follow-up: Evolution of quantitative viraemia in serum Evolution of quantitative viraemia in
circulating lymphocytes Evolution of quantitative viraemia in total blood
- Studying viral genotypes
;
Time Perspective: Prospective
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