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Chronic Disease clinical trials

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NCT ID: NCT01969539 Terminated - Clinical trials for Pulmonary Disease, Chronic Obstructive

Ventilator Adapters for Combivent Respimat

Start date: October 2013
Phase: Phase 4
Study type: Interventional

The general aim of this 1-day, open label, non-randomised, trial is to characterize the performance of two adapter devices designed to permit use of the Respimat® inhaler with patients requiring mechanical ventilation.

NCT ID: NCT01963156 Terminated - Diabetes Mellitus Clinical Trials

Synchronization to Improve Non-Adherence to Cardiovascular Medications

SyNCMed
Start date: November 2013
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate if synchronizing when patients with diabetes and/or coronary artery disease fill their prescriptions improves long-term adherence to these medications.

NCT ID: NCT01873534 Terminated - Clinical trials for Anemia of Chronic Disease

A Phase 2A Trial of FMX-8 Treatment for Anemia in Patients With ESRD on Hemodialysis HD

Start date: June 2013
Phase: Phase 2
Study type: Interventional

The trial is an uncontrolled, open-label, parallel group clinical trial. Approximately 10 subjects per dose group in 3 groups will be treated twice weekly for a total of 9 doses, followed by a 4-week observation period. Eligible subjects who have Hgb ≥10.5 g/dL and have stable Hgb levels will start the washout period of one to eight weeks. During the washout period, 30 subjects whose Hgb are < 10.0 will complete the baseline assessment to confirm their eligibility. Eligible subjects will be randomly assigned to one of the 3 cohorts in a 1:1:1 ratio. Subjects will be admitted on the day of the first dose and stay in the clinic overnight for pharmacokinetic (PK) sampling after the first (day 1) and the last dose (day 29). FMX-8 will be administered as 30 min i.v. infusion. After the 29-day treatment period, the trial subjects will be observed for an additional 28 days to allow safety and immunogenicity assessments.

NCT ID: NCT01830829 Terminated - Clinical trials for Benign Prostatic Hyperplasia

JALYN for Benign Prostatic Hyperplasia (BPH) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Start date: April 2013
Phase: Phase 3
Study type: Interventional

Benign Prostatic Hyperplasia (BPH) describes a common medical condition in men over 45 associated with voiding (obstructive) and storage (irritative) lower urinary tract symptoms and is in part related to prostate enlargement and obstruction. The standard medical therapy for this condition includes 5-alpha reductase inhibitors -5ARI (eg dutasteride) or alpha blocker therapy (eg tamsulosin), while the most effective medical therapy for BPH is the combination of these two medications. Approximately 10 to 20% of patients diagnosed with BPH also have either a diagnosis of or symptoms of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with typical genito-urinary pain and discomfort. This particular subset of patients of BPH patients with prostatitis symptoms pose a therapeutic dilemma. CP/CPPS (organ specific phenotype) is the third most prevalent prostate disease after prostate cancer and BPH. CP/CPPS is very prevalent (3-9% of men) and represents a significant percentage of urology outpatients (3-8% of male outpatient visits)resulting in a major impact on quality of life of patients and economic costs to society. Clinical phenotyping allows for prediction of the patients with CP/CPPS most likely to respond to dutasteride and tamsulosin (age, Lower Urinary Tract Symptoms [LUTS] and prostate related phenotypes [BPH]). It can be estimated that up to 30% of men currently diagnosed with CP/CPPS will include men with co-existing Benign Prostatic Hyperplasia (BPH) We propose to determine the efficacy of JALYN (dutasteride-tamsulosin combination) in the amelioration of prostatitis symptoms in men diagnosed with CP/CPPS who have the following clinical phenotype; age = 45 years, Lower Urinary Tract Symptoms (LUTS), enlarged prostate and Organ (prostate) specific symptoms (eg. BPH and CP/CPPS).

NCT ID: NCT01761695 Terminated - Clinical trials for Leukemia, Chronic Myeloid

Chronic Myelod Leukemia Registry at Asan Medical Center

Start date: January 2013
Phase:
Study type: Observational [Patient Registry]

The investigators would like to propose a prospective longitudinal observational cohort study for patients who will be diagnosed and/or treated for chronic myeloid leukemia at Asan Medical Center, Seoul, Korea, to use the acquired data for fundamentals of other retrospective analysis.

NCT ID: NCT01618721 Terminated - Clinical trials for Lung Disease, Interstitial

Detection and Characterization of Pulmonary Disease by Transthoracic Doppler (TTD)

Start date: December 2011
Phase: N/A
Study type: Observational

The study seeks to characterize data obtained from patients with a variety of lung diseases using ultrasound Doppler signals obtained from lung tissue. A standard ultrasound device in a Doppler mode is placed on the chest wall and the unique software the investigators have developed analyzes the signals reflected from within the lung. On the basis of of pilot studies performed previously the investigators expect to receive different signals from different diseases that will enable diagnosis of different lung diseases.

NCT ID: NCT01355809 Terminated - Clinical trials for Pulmonary Disease, Chronic Obstructive

Six-Minute Walk Test Comparing Helium/Oxygen to Nitrogen/Oxygen for COPD Rehabilitation

rehabilitate
Start date: December 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate effects of inspired gas mixtures on the distance walked by patients with severe Chronic Obstructive Pulmonary Disease (COPD) during a Six-Minute Walk test.

NCT ID: NCT01296854 Terminated - Clinical trials for Pulmonary Disease, Chronic Obstructive

The Effect of Spa Treatment on Chronic Obstructive Pulmonary Disease

BPCeaux
Start date: May 2011
Phase: N/A
Study type: Interventional

The primary objective of this study is to measure and compare the number of exacerbations (moderate or severe) between the two groups of randomized patients with and without thermal treatment). An exacerbation is defined by an increase in symptoms which justifies a unscheduled medical action: increased daily treatment and / or use of corticosteroids, and / or antibiotic therapy. Exacerbations are documented via prescriptions, hospitalisation reports or unscheduled visits.

NCT ID: NCT01179191 Terminated - Pain Clinical Trials

Conversion to Embeda With Rescue Trial

ConvERT
Start date: August 2010
Phase: Phase 4
Study type: Interventional

The purpose of the research study is to find out if opioid dependent chronic pain patients who are judged by their physician to be eligible to change their current opioid medicine and to participate in this study can be successfully adjusted to a stable dose of EMBEDA (morphine sulfate and naltrexone hydrochloride). The study will also assess each patient's risk for prescription opioid abuse, misuse and diversion.

NCT ID: NCT01069380 Terminated - Chronic Disease Clinical Trials

Resting Metabolic Rate in Chronic Bed-Ridden Patients

RMR
Start date: February 2010
Phase:
Study type: Observational

Research objective: to measure resting metabolic rate (REE) in long term, bed ridden, chronically ill patients and to compare their measured energy needs to standard REE equations