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Chronic Depression clinical trials

View clinical trials related to Chronic Depression.

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NCT ID: NCT05833087 Recruiting - Clinical trials for Treatment Resistant Depression

Schema Therapy for Patients With Chronic Treatment Resistant Depression

DEPRE-ST
Start date: April 17, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical study is to test a particular form of psychotherapy, called schema therapy, for people with difficult-to-treat depression (when depression is very lengthy or difficult to cure with antidepressive medication). Researchers will compare the group of participants receiving schema therapy to a group receiving standard psychotherapeutic treatment to see if schema therapy is more effective on depression symptoms and other important issues for the participant. The main question the study aims to answer is: - Can schema therapy be a more effective treatment for difficult-to-treat depression than other forms of psychotherapy offered in psychiatry today? People who have difficult-to-treat depression are a special group of patients who are more strained in a wide range of areas of life than other people with depression. They also more often have childhood trauma, as well as simultaneous personality disorder or personality traits that brings challenges in everyday life. Currently we can not offer a sufficiently effective psychiatric treatment for this group of people. Schema therapy was developed to help patients who do not have sufficient effect of the usual psychotherapeutic treatments. It also addresses personality disorders or problematic traits and childhood trauma directly in the therapy. The project will include 129 participants in total, of which half will receive schema therapy. Treatment is provided at four psychiatric centers at both the Southern and the Capital Region of Denmark. Participants receiving schema therapy will be given 30 sessions of weekly therapy, as well as the opportunity for the rest of the standard care package in the Danish secondary mental health system, that is, treatment with psychopharmacological medicine and meetings with next-to-kin and other parts of the participant's support system. Participants receiving the standard treatment will receive 6-16 sessions of individual or group therapy with a range of other psychotherapies that are not schema therapy, as well as the other parts of the standard care package as listed above. If schema therapy proves to be more effective for treatment of difficult-to-treat depression than the treatment offered today, it may give rise to more extended use of schema therapy in and outside psychiatry. This means that the toolbox for the treatment of difficult-to-treat depression is expanded with a new specialized and effective psychotherapeutic tool.

NCT ID: NCT05221567 Completed - Clinical trials for Persistent Depressive Disorder

Intensive Psychotherapy for Chronic Depression

Start date: January 1, 2012
Phase: N/A
Study type: Interventional

The study evaluates whether Intensive psychotherapy show superior effect on chronic depression over TAU

NCT ID: NCT02470988 Completed - Chronic Depression Clinical Trials

Does Disciplined Personal Involvement Precede Change in CBASP?

Start date: June 2015
Phase: N/A
Study type: Interventional

The purpose of the study is to investigate the process of symptom change in Cognitive Behavioural Analysis System of Psychotherapy (CBASP), and how the individual components of the therapy affect this change in individuals with chronic depression.

NCT ID: NCT00837564 Recruiting - Chronic Depression Clinical Trials

Cognitive Behavioural Analysis System of Psychotherapy (CBASp) Versus Escitalopram in Chronic Depression

Start date: February 2009
Phase: Phase 3
Study type: Interventional

60 patients with chronic major depressive disorder according to DSM-IV will be included into the study. Patients will be randomized to receive an open treatment either with CBASP, a psychotherapy for chronic depression, or pharmacological treatment with Escitalopram for 28 weeks.

NCT ID: NCT00596986 Active, not recruiting - Chronic Depression Clinical Trials

Getting Biased Treatment Study: How Psychotherapy and Antidepressants Change Brain Activity in Chronic Depression

GETTY
Start date: October 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.

NCT ID: NCT00006172 Completed - Depression Clinical Trials

Clinical Trials of Two Non-drug Treatments for Chronic Depression

Start date: April 2000
Phase: N/A
Study type: Interventional

This study investigates the potential efficacy of two nonpharmacologic treatments for nonseasonal depression, bright light exposure or high-density negative air ion exposure. Treatments are self-administered at home by the patient under close clinical supervision.