Chronic Coronary Syndrome Clinical Trial
Official title:
Computational mOdelliNg of myoCardial pERfusion to Improve ouTcome Prediction Based on cOronary Artery Stenosis and Atherosclerotic Plaque Burden Assessment by Computed Tomography
Detection of coronary stenosis is of utmost importance in identifying vulnerable patients. The combined use of coronary computed tomography angiography at rest (CCTA) and stress myocardial computed tomography perfusion (stress-CTP) provides both anatomic and functional analysis of coronary artery disease (CAD) using a single imaging test. Stress-CTP evaluates myocardial perfusion by measuring myocardial blood flow (MBF) under pharmacologically induced stress conditions. The drawback is that stress-CTP requires additional scanning and administration of an intravenous stressor with an increase in radiation exposure and potential stressor-related side effects. The investigators recently patented a computational model that can reproduce MBF under stress conditions (Italian patent n. 102021000031475 Metodo implementato mediante computer per la simulazione del flusso sanguigno miocardico in condizioni di stress [Computational method for simulating myocardial blood flow in stress conditions], half owned by Centro Cardiologico Monzino, half by Politecnico di Milano). On top of this, CCTA can characterize plaque type and identify adverse plaque characteristics. Moreover, biomechanics analysis allows the study of luminal stenosis and stress within the plaque. Finally, radiomics, extracting quantitative features from medical images to create big data and identify novel imaging biomarkers, can be applied to improve the diagnostic accuracy of coronary plaques.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06185530 -
SECURE Trial: Stress Echocardiography With Carotid Ultrasound vs Routine CT Coronary Angiography in Chronic Coronary Syndrome for Endpoints
|
N/A | |
Recruiting |
NCT05117866 -
Acetyl Salicylic Elimination Trial JAPAN: The ASET JAPAN Pilot Study
|
N/A | |
Recruiting |
NCT05727982 -
Identification of Molecular Mechanisms of Coronary Instability in Homogeneous Subsets of Patients With Acute Coronary Syndromes for the Implementation of Precision Medicine
|
||
Completed |
NCT06464276 -
Effectiveness and Tolerability of Trimetazidine 80mg Once Daily in Patients With Chronic Coronary Syndrome: The V-GOOD Study
|
||
Recruiting |
NCT03936504 -
Efficacy and Mechanism of TCCRP in Patients With Chronic Coronary Syndrome Under Fusion Cardiac Rehabilitation Model
|
N/A | |
Recruiting |
NCT05978089 -
Effect of Yangxinshi Tablet on Exercise Tolerance in Patients With Chronic Coronary Syndrome(MET STUDY)
|
Phase 4 | |
Recruiting |
NCT05875311 -
Telemonitoring System for Improving Continuity of Care in Patients With Chronic Coronary Syndrome (TELSINCORC)
|
N/A | |
Recruiting |
NCT05865600 -
Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome
|
N/A | |
Recruiting |
NCT05640752 -
Optimal Evaluation to Reduce Imaging Testing
|
N/A | |
Recruiting |
NCT05635994 -
Advanced Invasive Diagnosis for Patients With Chronic Coronary Syndromes Undergoing Coronary ANGIOgraphy (AID-ANGIO)
|
||
Recruiting |
NCT05583786 -
Intracoronary ECG ST-segment Shift Remission Time During Reactive Coronary Hyperemia
|
||
Completed |
NCT05592535 -
Outcomes With Fractional Flow Reserve in Chronic Coronary Syndrome
|
||
Recruiting |
NCT06255678 -
Angio-based Final Functional Effect of PCI
|
||
Recruiting |
NCT06275399 -
Comprehensive Assessment of Morphometric, Functional, Biomechanical and Biological Interactions Between Atherosclerotic Plaque and Platelets Within the Stenosed Coronary Artery
|
||
Not yet recruiting |
NCT06186336 -
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
|
||
Withdrawn |
NCT04738344 -
Very Long Versus Overlapping Stents in Long Coronary Lesions
|
N/A | |
Active, not recruiting |
NCT04135989 -
Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES
|
Phase 4 | |
Recruiting |
NCT05674630 -
Ticin for the Treatment of Coronary Lesions With Drug Eluting Ballons
|
Phase 4 | |
Recruiting |
NCT06171061 -
Yangxinshi Tablet Intervention for Exercise Capacity in Patients With Chronic Coronary Syndrome
|
Phase 4 | |
Recruiting |
NCT05379608 -
Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.
|
N/A |