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Chronic Cluster Headache clinical trials

View clinical trials related to Chronic Cluster Headache.

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NCT ID: NCT06124534 Recruiting - Clinical trials for Chronic Cluster Headache

Bilateral Occipital Nerve Field Stimulation for the Treatment of dtCCH

BONS
Start date: October 19, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the initial safety, tolerability, and effectiveness of the novel BliStim occipital nerve field stimulation therapy for the prevention of chronic cluster headaches. This is a prospective, first in human study.

NCT ID: NCT05868044 Recruiting - Clinical trials for Chronic Cluster Headache

REsponse to Combined SONS and ONS in Chronic Cluster headachE

RESPONSE
Start date: May 2, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to demonstrate the safe use of the PRIMUS System in subjects with chronic cluster headache. This is a single-centre, open label, prospective, first in human study to collect initial clinical data on the PRIMUS system for the treatment of chronic cluster headache.

NCT ID: NCT05477459 Not yet recruiting - Clinical trials for Chronic Cluster Headache

LSD to Improve Cluster Headache Impact Trial

LICIT
Start date: January 2024
Phase: Phase 2
Study type: Interventional

This study aims to investigate the efficacy and safety of LSD 25μg every 3 days for 3 weeks versus placebo in the treatment of chronic cluster headache (cCH). It is a 3-week double-blind placebo-controlled intervention study, preceded by a 4-week baseline observation period and followed by a 5-week post-treatment observation period. Primary objective: to evaluate the efficacy of LSD 25μg every 3 days for 3 weeks in cCH. Additional objectives: - To evaluate the safety of LSD 25μg every 3 days for 3 weeks in cCH. - To explore the exposure-response relationship of 25μg LSD in cCH. - To assess the effect of treatment with 25μg LSD on hypothalamic functional connectivity in patients with cCH, using resting state functional magnetic resonance imaging (rsMRI). - To explore cost-effectiveness of treatment with LSD in cCH. - To evaluate the efficacy of LSD on health-related quality of life.

NCT ID: NCT05064397 Completed - Clinical trials for Chronic Cluster Headache

A 1-year Trial to Inform About Long-term Exposure to Eptinezumab in Participants With Chronic Cluster Headache (cCH)

CHRONICLE
Start date: September 17, 2021
Phase: Phase 3
Study type: Interventional

The main goal of this trial is to inform about long-term safety and tolerability of eptinezumab in participants with chronic cluster headache.

NCT ID: NCT05023460 Active, not recruiting - Pain Clinical Trials

Treatment of Chronic Cluster Headache With TENS and ONS

HortONS
Start date: August 27, 2021
Phase: N/A
Study type: Interventional

The study is an investigator-initiated, prospective, randomized, placebo-controlled, double blind clinical trial that aims to investigate the effect of transcutaneous electrical nerve stimulation (TENS) and occipital nerve stimulation (ONS) on attack frequency and severity in patients with chronic cluster headache (CH). Study outline Month 1: Baseline. Establishment of a baseline profile of the participants CH attacks (severity, duration, medicine utilization etc), health-related quality of life (QoL) and symptoms of anxiety and depression. No active treatment. Follow-up visit after 30 days. Months 2-4: TENS period. All participants will receive TENS-treatment. Clinical follow-up visit by the end of month four. Months 5-7: Double-blinded, randomized experimental period. All participants will have an ONS-system (lead, impulse generator) implanted and will be randomized 1:1 to receive either 1) burst (paresthesia-free) ONS or 2) placebo (deactivated ONS system). Clinical follow-up visit by the end of month seven. Months 8-10: Open label period. All participants will receive tonic (conventional, paresthesia-inducing) ONS. Clinical follow-up visit by the end of month ten. During every study phase each participant will fill out a weekly electronic headache registration as well as answering questionnaires regarding health-related quality of life and symptoms of anxiety and depression before every follow-up visit.

NCT ID: NCT03244735 Completed - Clinical trials for Chronic Cluster Headache

Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: a Prospective Case Series

CCHD
Start date: January 2017
Phase: N/A
Study type: Interventional

Atkins diet is a nutritional regimen characterized by ad libitum protein and fat intake, but carbohydrate restriction. It is followed by millions of people around the word as a life-style, but in the last years was proposed as a treatment for the epilepsy, by its capacity to induce the state of ketosis. Since Authors observed that ketosis could be also useful in migraine, and migraine shares some pathophysiological features with cluster headache, The aim of the study is to test the efficacy of Atkins diet in Cluster Headache by an open label one harm observational study.

NCT ID: NCT02964338 Terminated - Clinical trials for Chronic Cluster Headache

A Study Comparing the Efficacy and Safety of Fremanezumab (TEV-48125) for the Prevention of Chronic Cluster Headache (CCH)

Start date: January 17, 2017
Phase: Phase 3
Study type: Interventional

The purpose of the current study is to evaluate the efficacy and safety of Fremanezumab (TEV-48125), in the prevention of CCH in adult participants.

NCT ID: NCT02797951 Completed - Clinical trials for Chronic Cluster Headache

A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache

Start date: July 13, 2016
Phase: Phase 3
Study type: Interventional

The main purpose of this study is to assess the long-term safety and tolerability of galcanezumab administered up to once monthly in participants with episodic or chronic cluster headache who have completed study I5Q-MC-CGAL (NCT02397473) or study I5Q-MC-CGAM (NCT02438826).

NCT ID: NCT02510729 Completed - Clinical trials for Chronic Cluster Headache

SPG Neurostimulation in Cluster Patients

Start date: July 2015
Phase: N/A
Study type: Interventional

We hypothesized that LF stimulation of the SPG would increase parasympathetic outflow, activate sensory afferents and provoke a cluster-like attack.

NCT ID: NCT02462395 Completed - Clinical trials for Chronic Cluster Headache

Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache

ANODECCH
Start date: September 2014
Phase: Phase 2/Phase 3
Study type: Interventional

Cluster headache is a primary headache that chiefly affects young men, and is less common than migraine. This disease can have devastating consequences due to the pain intensity (it is also called "suicide headache"), to the side effects of the drug preventive therapies, and to the resistance of some subtypes of the headache to all existing medications. Recent studies suggest that cluster headache could be associated with a decrease of the activity of frontal areas involved in descending pain control, in particular the subgenual anterior cingulate cortex. The aim of this pilot study is to activate these areas with a non-invasive neurostimulation technique, called transcranial direct current stimulation, as a preventive treatment for cluster headache sufferers.