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Clinical Trial Summary

The aim of this study is to investigate whether the combination of durvalumab and olaparib in the maintenance setting after initial chemotherapy and durvalumab will benefit patients with locally advanced or metastatic cholangiocarcinoma.


Clinical Trial Description

The primary objectives are (i) To describe the efficacy of PARPi and PDL1 inhibition in the maintenance setting of metastatic cholangiocarcinomas. (ii) To refine selection of the patient population who are most likely to benefit from the combination of PDL1 (Durvalumab) and PARP (Olaparib) inhibition in the maintenance setting following initial chemotherapy (cisplatin + gemcitabine + Durvalumab) (post hoc translational analysis). The secondary objectives are (i) To evaluate toxicity of the combination of durvalumab and olaparib. (ii) To evaluate progression-free and overall survival with the combination of durvalumab and olaparib (PFS, OS). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06441747
Study type Interventional
Source Australasian Gastro-Intestinal Trials Group
Contact Sukanya Sathyamurthie
Phone +61 2 7208 2719
Email sukanya@gicancer.org.au
Status Not yet recruiting
Phase Phase 2
Start date August 2024
Completion date August 2028

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