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Cholangiocarcinoma clinical trials

View clinical trials related to Cholangiocarcinoma.

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NCT ID: NCT02807181 Not yet recruiting - Clinical trials for Intrahepatic Cholangiocarcinoma

CIS-GEM Chemotherapy+/- SIRT as 1st Line Treatment of Patients With Unresectable Intrahepatic Cholangiocarcinoma

SIRCCA
Start date: July 2016
Phase: N/A
Study type: Interventional

The study will evaluate the benefit of applying Selective Internal Radiation Therapy (SIRT) using SIR-Spheres Y-90 resin microspheres prior to receiving systemic chemotherapy treatment (cisplatin-gemcitabine, or CIS-GEM) in patients with unresectable intrahepatic cholangiocarcinoma. Half of the patients will be randomized to CIS-GEM chemotherapy plus SIRT, and half of the patients will be randomized to CIS-GEM alone.

NCT ID: NCT02801500 Not yet recruiting - Clinical trials for Hilar Cholangiocarcinoma

Superior Bilioenteric Anastomosis by Magnetic Compressive Technique

CTREG
Start date: June 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the magnetic compressive anastomosis has a better outcomes than traditional manual anastomosis on superior bilioenteric anastomosis.

NCT ID: NCT02798510 Recruiting - Clinical trials for Malignant Neoplasm Other Gallbladder/Extrahepatic Bile Duct

Clinical Trial of Adjuvant Chemotherapy Followed by Concurrent Chemoradiotherapy Compared With Adjuvant Chemotherapy Alone in Patients With Gallbladder Carcinoma and Extrahepatic Cholangiocarcinoma

Start date: April 2016
Phase: Phase 3
Study type: Interventional

The present study is designed to determine whether adjuvant concurrent chemoradiotherapy improves overall survivals.

NCT ID: NCT02784795 Not yet recruiting - Breast Cancer Clinical Trials

A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

Start date: June 2016
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate the safety of the study drug known as LY3039478 in combination with other anticancer agents in participants with advanced or metastatic solid tumors.

NCT ID: NCT02773485 Recruiting - Cholangiocarcinoma Clinical Trials

Chemo Alone or in Combination With Radiation in Unresectable Cholangiocarcinoma

Start date: May 2015
Phase: Phase 3
Study type: Interventional

The study evaluates impact of high dose radiation on overall survival in patients with unresectable nonmetastatic cholangiocarcinoma. The study randomizes patient between systemic chemotherapy alone and systemic chemotherapy and high dose radiation

NCT ID: NCT02762721 Recruiting - Cholangiocarcinoma Clinical Trials

Analysis of Oncogenes in Intrahepatic Cholangiocarcinoma or Mixed Hepatocellular-Cholangiocarcinoma in Tumor Tissue Samples

Start date: May 2016
Phase: N/A
Study type: Observational

The primary objective of this study is to estimate the frequency of FGFR2 fusions in archived intrahepatic cholangiocarcinoma (iCCA) or mixed hepatocellular-cholangiocarcinoma (HCC-CCA) tumor samples

NCT ID: NCT02757859 Recruiting - Cholangiocarcinoma Clinical Trials

High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Start date: February 2016
Phase: N/A
Study type: Interventional

This randomized clinical trial studies how well high volume washing of the abdomen works in increasing survival after surgery in patients with pancreatic cancer that can be removed by surgery. High volume washings may remove free floating cancers present after surgery and help prolong survival in patients with pancreatic cancer.

NCT ID: NCT02730611 Recruiting - Metabolic Syndrome Clinical Trials

Metabolic Syndrome, Bile Acids, Hepatocellular Carcinoma and Cholangiocarcinoma

METSLIVER
Start date: April 2016
Phase: N/A
Study type: Observational

Increasing rates of highly malignant hepatocellular carcinoma (HCC) and biliary tract cancers (GBTC) observed in Western populations may be related to obesogenic lifestyle factors and their metabolic consequences, such as metabolic syndrome (MetS), inflammation and altered production of bile acids (BA). Such lifestyle behaviours may induce changes in the gut microflora which in turn affect BA profiles, increasing their carcinogenicity. Some elevated BA may be oncogenic in exposed liver, bile ducts and gall bladder. Vertical sleeve gastrectomy may change bile acid composition. The aims of this study are: 1. whether specific presurgical bila acid profiles are predictive of efficacy of vertical sleeve gastrectomy, reflective of liver function and metabolic dysfunction; 2. whether specific presurgical bile acid profiles are predictive of the efficacy of sleeve gastrectomy

NCT ID: NCT02725073 Recruiting - Adverse Events Clinical Trials

Photodynamic Therapy in Locally Advanced Hilar Cholangiocarcinoma

PDT
Start date: January 2016
Phase: Phase 2
Study type: Interventional

To determine the safety and efficacy of photodynamic therapy with a novel photosensitizer and a flexible laser probe in locally advanced hilar cholangiocarcinoma.

NCT ID: NCT02699606 Not yet recruiting - Tumor or Lymphoma Clinical Trials

A Study to Evaluate the Clinical Efficacy of JNJ-42756493, A Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine KinaseInhibitor, In Asian Participants With Advanced Non-Small-Cell Lung Cancer, Urothelial Cancer, Gastric Cancer, Esophageal Cancer Or Cholangiocarcinoma

Start date: April 2016
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to evaluate objective response rate (ORR) as per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 of JNJ-42756493 in a molecularly-defined subset of Asian participants with non-small-cell lung cancer (NSCLC), gastric cancer, urothelial cancer, esophageal cancer and cholangiocarcinoma.