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Prospective Observational Study to Predict the Response of Biliary Tract Tumors to Immunotherapy

Cholangiocarcinoma Clinical Trial

Official title:
Prospective Observational Study on Prediction of Response to First-line Immunotherapy in Patients With Biliary Tract Tumors

Clinical Trial Summary

A prospective, observational study to explore multidimensional biomarkers for predicting the efficacy of immunotherapy In biliary tract tumors

Clinical Trial Description

Patient with unresectable advanced or metastatic biliary tract tumors will be enrolled and plan to receive PD-1/PD-L1 inhibitors combined with chemotherapy as first-line treatment. To explore the biomarkers, tumor tissues, acquired from puncture biopsies at baseline, will be collected and investigated by genomic panel sequencing , transcriptome sequencing, and mIHC. Meanwhile, baseline peripheral blood and feces were also collected for detection of plasma proteins, genomes, and metagenomes. Finally, the investigators will analysis and explore predictive biomarkers of immunotherapy in biliary tract tumors. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06048289
Study type Observational
Source Zhejiang Cancer Hospital
Contact Jieer Ying, Dr
Phone 13858195803
Email jieerying@aliyun.com
Status Recruiting
Phase
Start date September 14, 2023
Completion date March 31, 2025
View Details
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