Chlamydia Trachomatis Infection Clinical Trial
Official title:
Phase 2B Double-blind Placebo-controlled Efficacy Trial of EVO100 (Previously Known as Amphora ® Gel) for the Prevention of Acquisition of Urogenital Chlamydia Trachomatis Infection
Phase 2B double-blind placebo-controlled efficacy trial of EVO100 (previously known as Amphora ® Gel) for the prevention of acquisition of urogenital Chlamydia trachomatis infection
Primary: To determine if intravaginal EVO100 reduces the risk of urogenital Chlamydia
trachomatis (CT) infection.
Secondary: To determine if intravaginal EVO100 reduces the risk of urogenital Neisseria
gonorrhoeae (GC) infection.
Exploratory:To determine if EVO100 use rate (subject adherence to instructed use) has an
effect on proportion of subjects who experience CT or GC infection during the study
intervention period.
Primary Outcome Measures: Proportion of subjects who experience urogenital CT infection
during the study intervention period (incident infection of CT).
Secondary Outcome Measures: Proportion of subjects who experience urogenital GC infection
during the study intervention period (incident infection of GC).
Exploratory Outcome Measures:
- Compliance with EVO100 usage during study (rate of product use adherence).
- Sensitivity analyses of the primary parameter (proportion of subjects who experience at
least one CT or GC infection during the study intervention period) will be performed for
the following:
- Subjects with ≥20%, ≥40%, ≥60% and ≥80% product use adherence
- Subject Satisfaction
- Sexual satisfaction
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04269434 -
GonoScreen: Efficacy of Screening STIs in MSM
|
N/A | |
Active, not recruiting |
NCT04139629 -
Cohort Study Investigating the Association Between Antichlamydial Antibody Positivity and ART Outcomes in Women With TFI
|
N/A | |
Completed |
NCT03098329 -
Check it: A New Approach to Controlling Chlamydia Transmission in Young People
|
N/A | |
Recruiting |
NCT03862495 -
Genital CT Treatment to Pregnant Women to Prevent Adverse Pregnancy Outcomes: A Pilot RCT
|
N/A | |
Completed |
NCT05307991 -
Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe
|
||
Terminated |
NCT02083276 -
Mecillinam for Treatment of Genital Chlamydia Infection
|
Phase 2 | |
Active, not recruiting |
NCT06131749 -
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
|
||
Completed |
NCT03568695 -
Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples
|
N/A | |
Completed |
NCT01448876 -
Incubation Time and Test of Cure of Chlamydia Trachomatis
|
N/A | |
Not yet recruiting |
NCT06369220 -
A Study of the Cobas® Liat CT/NG/MG Test Versus Current Standard Practice for Managing Participants at Increased Risk of Sexually Transmitted Infections
|
N/A | |
Not yet recruiting |
NCT06395675 -
Clinical Evaluation of the ID NOW™ CT/NG Test
|
N/A | |
Completed |
NCT03970850 -
NeuMoDx PrEDiCTiNG Study Evaluation Plan
|
N/A | |
Completed |
NCT01631201 -
Safety and Efficacy Study of Rifalazil for the Treatment of Chlamydia Trachomatis Infection in Women
|
Phase 2 | |
Completed |
NCT05216744 -
Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
|
Phase 2 | |
Recruiting |
NCT05581160 -
Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)
|
N/A | |
Not yet recruiting |
NCT03532464 -
Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection
|
Phase 4 | |
Not yet recruiting |
NCT06234943 -
Pharmacy-based Testing and Treatment for Gonorrhea and Chlamydia
|
N/A | |
Active, not recruiting |
NCT04050540 -
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
|
Phase 4 | |
Completed |
NCT04955717 -
Antenatal Chlamydia Trachomatis and Neisseria Gonorrhoeae Testing to Prevent Adverse Neonatal Consequences
|
N/A | |
Active, not recruiting |
NCT05666778 -
Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
|
Phase 2 |