Childhood Obesity Clinical Trial
— 2-BIGOfficial title:
Twins Born in Guangzhou Cohort Study
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.
Status | Recruiting |
Enrollment | 1000 |
Est. completion date | December 31, 2038 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A to 18 Years |
Eligibility | Inclusion Criteria: 1. Live twins delivered in Guangzhou Women and Children's Medical Center 2. Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years 3. Baseline information during pregnancy available |
Country | Name | City | State |
---|---|---|---|
China | Guangzhou Women and Children's Medical Center | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Guangzhou Women and Children's Medical Center |
China,
Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-02 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Neurodevelopment at early childhood | Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules. | At age of 1 year old | |
Primary | Intelligence quotient | Assessed using the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition including 5 verbal and 3 performance subtests. Intelligence quotient ranges 40-160, in which under 70 is defined as mental retardation. The total score was calculated by an online system. | At age of 6 years old | |
Primary | Change of gene expression during childhood | DNA methylation, histone acetylation etc. assessed by analyses of blood samples | Age at 1 year , 6 years, 12years and 18years | |
Secondary | Change of intestinal flora during early childhood | Assessed by analyses of stool samples | Age at 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years | |
Secondary | Changes of body composition and bone density during early childhood | Body composition and bone density are assessed using Dual Energy X-Ray Absorptiometry | At birth, age of 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years | |
Secondary | Height in kilometer changes during childhood | Measured by nurses in clinic | At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year | |
Secondary | Weight in kilogram changes during childhood | Measured by nurses in clinic | At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year |
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