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Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

Childhood Cancer Clinical Trial

Official title:
Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

Clinical Trial Summary

A companion platform trial to test novel targeted agents based on the patient's tumor profile.

Clinical Trial Description

Both Australia (Zero Childhood Cancer) and Canada (PROFYLE) have developed precision oncology programs for the pediatric population through which samples from childhood/adolescent cancers undergo in depth genetic profiling. OPTIMISE is a companion platform trial, which will link patients to novel targeted agents based on their tumor profile. The trial will have multiple basket arms based on the most common genetically altered pathways the investigators have identified in these childhood cancers. Each arm of the trial will be histopathology agnostic and test a rational, novel combination therapy, to maximise potential clinical benefit. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06208657
Study type Interventional
Source Australian & New Zealand Children's Haematology/Oncology Group
Contact National Study Coordinator
Phone +61293821730
Email SCHN-OPTIMISE@health.nsw.gov.au
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date March 2024
Completion date December 2035
View Details
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