Chest Pain Clinical Trial
— MID-EPICOfficial title:
Myocardial Ischemia Detection for Early Identification of Patients With Ischemic Chest Pain
Verified date | July 2017 |
Source | University of Pittsburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to evaluate whether new novel markers from the clinical
electrocardiogram (EKG), which have been used as non-invasive measures of heart disease, can
detect coronary artery disease in patients with chest pain. The researchers are especially
interested in studying how changes in these unique waves evolve over time with rest and
activity. It is hoped that the findings will be helpful in differentiating patients with
cardiac chest pain at emergency departments from those with non-cardiac chest pain, as early
identification can accelerate treatment and save lives.
Eligible participants are those age 18 and older who have been referred for a nuclear stress
test at University of Pittsburgh Medical Center Presbyterian Hospital to rule out coronary
artery disease as part of their clinical care.
Status | Completed |
Enrollment | 50 |
Est. completion date | December 2016 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - adults > 18 years of age - referred for nuclear cardiac stress testing for suspected coronary artery disease. There will be no restrictions to sex or race. Children and teens are less likely to have ischemic etiology of chest pain, justifying their exclusion. To optimize the clinical utility, there will be no exclusion criteria based on previous medical history, medications, or presenting chief complaint; all consecutive patients will be eligible. Exclusion Criteria: - Patients with un-interpretable ECGs or their ECG shows known secondary repolarization abnormalities (i.e. bundle branch blocks, ventricular hypertrophy, channelopathies, early repolarization) will be excluded. Of note, as per clinical guidelines, these patients do not get usually referred for exercise treadmill testing. This will improve the recruitment process of this study. |
Country | Name | City | State |
---|---|---|---|
United States | University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pittsburgh |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Myocardial ischemia | The primary outcome is the presence of radionuclide evidence of focal myocardial ischemia evidenced on nuclear cardiac stress testing (SPECT results). | 1-2 days per hospital SPECT protocol |
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