Role of Curcumin in Paclitaxel Induced PN

Chemotherapy-induced Peripheral Neuropathy Clinical Trial

Official title: Evaluating the Effect of Curcumin in Preventing Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients

Status Not yet recruiting

Clinical Trial Summary

Paclitaxel induced peripheral neuropathy is the most common and serious side effect associated with Paclitaxel treatment in breast cancer patients receiving Paclitaxel.

The efficacy of antioxidant molecules as neuroprotective strategies to preventing the development of peripheral neuropathy has been investigated in preclinical and clinical studies. Vitamin E and Glutathione have been explored as adjuvant therapies to preventing taxane-induced peripheral neuropathy. Other tested neuroprotective treatments with limited success include amifostine, glutamine and acetyl l-carnitine. Curcumin's antioxidant capacity is similar to other potent antioxidants, such as trolox (a vitamin E analog). Curcumin inhibits lipid peroxidation in different tissues, regulates intracellular levels of antioxidant enzymes (e.g., catalase, glutathione peroxidase and superoxide dismutase) and is an effective intracellular reactive oxygen species (ROS) scavenger.

The investigators are going to investigate the neuroprotective effect of Curcumin against Paclitaxel induced peripheral neuropathy.

Clinical Trial Description

The work is a prospective, randomized, open label controlled study. A total of 90 breast cancer female patients will be enrolled in the study. Eligible patients will simply be randomized using random allocation generator, after the end of anthracycline adjuvant therapy to one of two groups, Group I: will receive paclitaxel regimen plus 2g of curcumin Group II: will receive paclitaxel regimen only.

The cases involved in the study will be recruited from Ain Shams Teaching Hospital.

All patients presenting to the department were assessed for eligibility according to certain inclusion and exclusion criteria.

Details of the research steps that the subscriber will be exposed to:

• Base line evaluation then alignment in either intervention or control group either for taking the interventional drug or standard of care in control group.

• Blood samples will be collected at baseline.

• Patient will be given a weekly supply of the medication and will be asked to take his prescribed dose daily.

• Every week all patients will be asked about their symptoms and if they experience any adverse drug reaction.

• Patients will receive the interventional drug until the last paclitaxel dose will be taken.

• After 3 months, another full clinical examination and blood sample will be obtained. ;

Related Conditions & MeSH terms

• Chemotherapy-induced Peripheral Neuropathy
• Peripheral Nervous System Diseases

• NCT number: NCT05966441
• Study type: Interventional
• Source: Ain Shams University
• Contact: Sherif Gawish, master student
• Phone: 00201019700299
• Email: sherif.gawish2020@gmail.com
• Status: Not yet recruiting
• Phase: Phase 2
• Start date: August 30, 2023
• Completion date: March 10, 2024