Clinical Trials Logo

Clinical Trial Summary

This is a cross-sectional pilot study. The investigators seek to obtain early information pertaining to the relationship between measurements of myocardial perfusion reserve and myocardial fibrosis after receipt of Anthracycline-based chemotherapy (≥2 years prior).


Clinical Trial Description

The primary objective of this cross-sectional pilot study is to determine the myocardial perfusion reserve index (MPRI) in cancer survivors treated with anthracycline chemotherapy relative to similarly aged healthy comparators without a history of cancer treatment. Hypothesis: Cancer survivors treated with anthracycline chemotherapy will have a lower MPRI than similarly aged healthy comparators without a history of cancer treatment.The secondary objective of this cross-sectional pilot study is to determine if MPRI is associated with myocardial fibrosis measured non-invasively with cardiovascular magnetic resonance imaging. Hypothesis: MPRI will be inversely associated with fibrosis burden Study participants will be consented with pre-study data collection recorded. No randomization will occur as this is a cross-sectional study. Participants in both the cancer survivor and control groups will complete one study visit. No follow-up will be completed. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03191461
Study type Observational
Source Virginia Commonwealth University
Contact Jennifer H Jordan, PhD
Phone (804) 628-6239
Email Jennifer.Jordan@vcuhealth.org
Status Recruiting
Phase
Start date November 13, 2017
Completion date July 31, 2024

See also
  Status Clinical Trial Phase
Terminated NCT03940651 - Cardiac and Renal Biomarkers in Arthroplasty Surgery Phase 4
Completed NCT01688648 - Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft N/A
Completed NCT04794062 - Myocardial Injury and Quality of Life After COVID-19
Recruiting NCT04750616 - NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial Phase 2
Recruiting NCT04615871 - Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19 Phase 2
Completed NCT05691764 - Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery N/A
Withdrawn NCT04139655 - Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study N/A
Completed NCT04436016 - PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery Phase 4
Completed NCT05748691 - Switching From Cardiac Troponin I to T
Completed NCT03338504 - Determining the Mechanism of Myocardial Injury and Role of Coronary Disease in Type 2 Myocardial Infarction
Recruiting NCT03013634 - Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation N/A
Completed NCT00007358 - Dexamethasone Treatment for Congenital Heart Block (CHB) in Newborns With Lupus N/A
Recruiting NCT05714618 - MR Evidence of Cardiac Inflammation Post-Stroke
Recruiting NCT04624503 - Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19
Active, not recruiting NCT03339180 - Cardiac Injury in Patients With Influenza
Completed NCT03010839 - Cardiopulmonary Protective Effects of Modified Remote Ischaemic Preconditioning in Mitral Valve Replacement Surgery N/A
Recruiting NCT04743765 - HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial N/A
Enrolling by invitation NCT03253835 - Cardiac Blood Flow Patterns Associated With Left Ventricular Myocardial Damage
Completed NCT00817791 - Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery N/A
Completed NCT04149314 - The "Hypotension Prediction Index" in Patients Undergoing Lung Surgery N/A