Dosimetric Analysis of Vaginal Cuff Brachytherapy in Endometrial Carcinoma

Status Completed

Clinical Trial Summary

The purpose of this study is to investigate the effect of certain variables such as the fullness of the patients bladder and the position of the treatment applicator on the dose of radiation that other organs such as the bladder and the rectum receive during radiation treatment for endometrial carcinoma.

Clinical Trial Description

- This study is separated into 2 phases. In phase 1, patients will be asked to have their bladder full for the second planned insertion of the brachytherapy applicator and empty for the third insertion. For phase 2, the effect of cylinder angle on normal tissue dosimetry will be investigated. Of the two bladder states assessed in phase 1 (empty or full), the one deemed to give the lower dose to the total amount of bladder tissue will be considered the standard and applied to all patients in phase 2.

- In phase 1, to standardize bladder filling, patients will be asked to empty their bladder, then to drink 32 oz of water one and a half hours before the CT scan. The patient will undergo a treatment-planning scan after the brachytherapy cylinder is inserted and before brachytherapy treatment.

- In phase 2, patients will be asked to fill or empty their bladder according to the results of phase 1. The vaginal cylinder will be placed horizontally for the second treatment. The cylinder will then be angled at a specific angle for the subsequent treatment.

- A history and physical exam will be performed within 2 weeks of study entry, then at 14 days, 90 days, and 180 days following the completion of therapy. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00165126
Study type	Observational
Source	Dana-Farber Cancer Institute
Contact
Status	Completed
Phase	N/A
Start date	January 2004
Completion date	July 2008

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04067882` - Validation of the Genetic Signature 354849 as a Prognostic Method
Completed	`NCT00329589` - A Trial Using Velcade Plus Chemoradiation for Central Nervous System, Head and Neck, and Cervical Cancer Patients	Phase 1
Recruiting	`NCT05743517` - Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)	N/A
Completed	`NCT05234112` - Prevention and Screening Towards Elimination of Cervical Cancer	N/A
Completed	`NCT04258553` - Thiol Disulfide Balance in Cervix Cancer
Completed	`NCT03956498` - Impact of a Sexological Follow-up on the Sexual Function in Patients With Cervix or Vaginal Cancer Treated by Radiotherapy and Brachytherapy	N/A
Active, not recruiting	`NCT04357873` - Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations	Phase 2
Completed	`NCT00379743` - Partnership for Healthy Seniors	N/A
Completed	`NCT00509444` - Cancer Prevention and Treatment Among African American Older Adults: Treatment Trial	Phase 3
Recruiting	`NCT06022029` - A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.	Phase 1
Recruiting	`NCT06116019` - Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
Completed	`NCT04072913` - Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix	N/A
Active, not recruiting	`NCT06452004` - Validation of Artificial Intelligence as Decision Support System in VIA (PRESCRIP-TEC)	N/A
Recruiting	`NCT04651127` - Anti-PD-1 Antibody Combined With Histone Deacetylase Inhibitor in Patients With Advanced Cervical Cancer	Phase 1/Phase 2
Recruiting	`NCT06010875` - A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors	Phase 1
Completed	`NCT02552121` - Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors	Phase 1/Phase 2
Completed	`NCT02001623` - Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors	Phase 1/Phase 2
Completed	`NCT02997553` - Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery	Phase 3
Terminated	`NCT02233387` - PET CT With HX4 in Cervix Cancer	Phase 2
Completed	`NCT01766284` - Study of the Diagnostic Efficacy of "Real Time" Niris 1300e Optical Coherence Tomography (OCT) Imaging System in the Management of Pre-invasive and Invasive Neoplasia of the Uterine Cervix	N/A