Cervical Cancer Clinical Trial
Official title:
Evaluation of Cyclooxygenase-2 Expression in Normal Cervix, Cervical Intraepithelial Neoplasia and Early Invasive Squamous Cell Carcinoma With Correlation to Parameters of Invasion and Angiogenesis
RATIONALE: Studying samples of tissue from patients with or without cancer in the laboratory
may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This laboratory study is looking at cyclooxygenase-2 expression in tissue samples
from patients with a normal cervix, cervical intraepithelial neoplasia, or early invasive
cervical cancer.
OBJECTIVES:
- Determine cyclooxygenase-2 (COX-2) levels in biopsy or surgical specimens from patients
with normal cervical epithelium, cervical intraepithelial neoplasia, or microinvasive
squamous cell carcinoma of the cervix.
- Correlate COX-2 levels with histological diagnosis and parameters of invasion (i.e.,
matrix metalloproteinase, microvessel count, and VEGF).
OUTLINE: Paraffin-embedded tissue samples are analyzed by immunohistochemistry for evaluation
of cyclooxygenase-2 levels, microvessel count, and matrix metalloproteinase and VEGF
expression.
Medical data for study analysis is obtained by retrospective review of patient charts.
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