Pelvic Exenteration in Treating Patients With Recurrent Cervical Cancer

Status Completed

Clinical Trial Summary

This phase II trial is studying how well pelvic exenteration works in treating patients with recurrent cervical cancer. Pelvic exenteration may be effective in treating recurrent cervical cancer.

Clinical Trial Description

PRIMARY OBJECTIVE:

I. Correlate progression-free survival and overall survival with tumor size, time interval between primary cancer management and pelvic exenteration, and presence or absence of pelvic sidewall fixation by clinical examination in patients with recurrent cervical cancer treated with pelvic exenteration.

SECONDARY OBJECTIVES:

I. Determine quality of life of patients treated with this procedure. II. Correlate quality of life with reconstructive technique (e.g., no ostomy or ≥ 1 ostomy) in patients treated with this procedure.

OUTLINE:

Patients undergo pelvic exenteration within 14 days after study entry. Quality of life is assessed at baseline and at 6, 12, and 24 months after surgery. After completion of study treatment, patients are followed within 30 days, every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00217633
Study type	Interventional
Source	Gynecologic Oncology Group
Contact
Status	Completed
Phase	Phase 2
Start date	January 2006

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02562729` - Complete Nerve-Sparing Radical Hysterectomy for Cervical Cancer	Phase 2
Completed	`NCT00416455` - Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer	Phase 1/Phase 2
Completed	`NCT00054444` - Radiation Therapy and Chemotherapy in Treating Patients With Locally Advanced Cervical Cancer	Phase 1
Recruiting	`NCT05210348` - Clinical Evaluation of Detection of High Risk HPV in Urine
Active, not recruiting	`NCT02140021` - Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer	N/A
Completed	`NCT00068549` - Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer	Phase 1
Completed	`NCT01711515` - Chemoradiation Therapy and Ipilimumab in Treating Patients With Stages IB2-IIB or IIIB-IVA Cervical Cancer	Phase 1
Terminated	`NCT00924066` - Ixabepilone to Treat Cervical Cancer	Phase 2
Completed	`NCT00559377` - FDG and FMISO PET Hypoxia Evaluation in Cervical Cancer	Phase 2
Completed	`NCT00309959` - ABI-007 in Treating Patients With Persistent or Recurrent Cervical Cancer	Phase 2
Active, not recruiting	`NCT05613283` - Primary Cervical Cancer Screening by Self-sampling HPV Test
Recruiting	`NCT03742869` - HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
Withdrawn	`NCT03834571` - Testing the Addition of Paclitaxel and Carboplatin Given After Standard Chemotherapy and Radiation for Cervical Cancer in HIV-positive Women	Phase 2
Completed	`NCT01266460` - Vaccine Therapy in Treating Patients With Persistent or Recurrent Cervical Cancer	Phase 2
Completed	`NCT00064077` - Comparison of Four Combination Chemotherapy Regimens Using Cisplatin in Treating Patients With Stage IVB, Recurrent, or Persistent Cancer of the Cervix	Phase 3
Active, not recruiting	`NCT02257528` - Nivolumab in Treating Patients With Persistent, Recurrent, or Metastatic Cervical Cancer	Phase 2
Active, not recruiting	`NCT02466971` - Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers	Phase 3
Completed	`NCT02164461` - Axalimogene Filolisbac (ADXS11-001) High Dose in Women With Human Papillomavirus (HPV) + Cervical Cancer	Phase 1
Completed	`NCT01281852` - Paclitaxel, Cisplatin, and Veliparib in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer	Phase 1
Active, not recruiting	`NCT04622670` - Yoga Therapy During Chemotherapy and Radiation Treatment for the Improvement of Physical and Emotional Well-Being in Patients With Stage IB2-IIIB Cervical Cancer	N/A