Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic Stroke

Status Completed

Clinical Trial Summary

It has proposed the use of ST without microbubble treatment in randomized association with both intravenous and intra-arterial thrombolysis, but combined treatment (rtPA + U.S.) associated with MB diagnostic not yet been investigated in a randomized study.

The aim of this study is to evaluate efficacy of the combined treatment (r-rtPA+US+MB) vs the standard rtPA treatment in a randomized study in consecutive patients with acute ischemic stroke.

We expect to demonstrate that the combined treatment (rtPA+US+MB) will be statistically superior to standard treatment in terms of recanalization rate.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01678495
Study type	Interventional
Source	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Contact
Status	Completed
Phase	Phase 2
Start date	August 2012
Completion date	July 2015

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT02885545` - The Strategy to Prevent Hemorrhage Associated With Anticoagulation in Renal Disease Management (STOP HARM) Trial	Phase 4
Completed	`NCT02478177` - Addressing Real-world Anticoagulant Management Issues in Stroke
Not yet recruiting	`NCT04378946` - Error Augmentation Motor Learning Training Approach in Stroke Patients	N/A
Completed	`NCT00609115` - Sub-Acute Stroke Rehabilitation With AMES	N/A
Completed	`NCT04103034` - A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers	Phase 1
Completed	`NCT02207023` - Healthy Lifestyles After Stroke - Stroke Coach	N/A
Completed	`NCT03417349` - Safety and Effectiveness of SOFIA™/SOFIA™ PLUS for Direct Aspiration in Acute Ischemic Stroke
Recruiting	`NCT02587949` - The Correlation Between Hair Cortisol Level of Acute Stroke or Its Long Term Disability.
Completed	`NCT02735148` - The Effects of Body Weight Supported Treadmill Training On Balance In Stroke Patients	N/A
Completed	`NCT02759627` - Does Isolated Robotic-Assisted Gait Training Improve Functional Status, Daily Living And Quality Of Life In Stroke?	N/A
Terminated	`NCT02465034` - Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke	N/A
Completed	`NCT01133106` - Living Well With Stroke	N/A
Completed	`NCT00061022` - Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke	Phase 3
Completed	`NCT02725944` - Prediction and Detection of Occult Atrial Fibrillation in Patients After Acute Cryptogenic Stroke and TIA
Not yet recruiting	`NCT04870684` - Thromboelastometry and Ischemic Stroke (ThromboPredict)
Terminated	`NCT03094715` - Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window	N/A
Completed	`NCT05013762` - Fast Arm Motor Skill Training	N/A
Not yet recruiting	`NCT01205490` - Changes in Cerebral Blood Flow With Spinal Manipulative Therapy vs. Voluntary Motion	N/A
Recruiting	`NCT01144650` - Dapsone for Acute Ischemia Stroke Study	Phase 2/Phase 3
Completed	`NCT00608582` - Transcranial Magnetic Stimulation to Improve Speech in Aphasia	Phase 2