Brain Stimulation Enhance Post-stroke Walking Survivors & Healthy Adults

Status Not yet recruiting

Clinical Trial Summary

Recent studies showed that a non-invasive, low-intensity brain stimulation called transcranial direct current stimulation (tDCS) can effectively increase motor neuron excitability in the brain and therefore promotes functional recovery after stroke. Thus, the overall purpose of this research project is to examine the effect of brain stimulation on motor skill learning in stroke survivors.

Clinical Trial Description

The specific aims and hypotheses are: Aim 1: To explore the trends of locomotor skill acquisition in stroke survivors after anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after sham tDCS (s-tDCS), and stroke with no brain stimulation (control; CON). Hypothesis (Aim 1): Stroke participants who receives a-tDCS will show a faster rate of learning a locomotor task compared to stroke participants who receive s-tDCS and stroke participants with no brain stimulation. Aim 2: To explore different trends of stimulation-induced improvements in learning capacity and neural activities between three groups: stroke group, healthy young group, and healthy older group. Hypothesis (Aim 2): Healthy young adults will have a greater degree of stimulation-induced improvements in learning capacity and neural excitation compared to older adults and stroke participants. Aim 3: To explore the trends of functional improvements post a-tDCS in stroke survivors. Hypothesis (Aim 3): Stroke participants who receives a-tDCS will show a greater improvements in functional performances compared to stroke participants who receive s-tDCS and stroke participants with no brain stimulation. Aim 4: To explore the accumulated, longitudinal trends of a four-week visuomotor stepping training in conjunction with brain stimulation on treadmill walking training and gait improvements for persons with chronic stroke. Hypothesis (Aim 4): Stroke participants who receives a-tDCS will show a greater degree of gait improvements compared to stroke participants who receive s-tDCS and stroke participants with no brain stimulation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06191549
Study type	Interventional
Source	The University of Texas Medical Branch, Galveston
Contact	Shih-Chiao Tseng, PhD
Phone	409-772-9555
Email	shtseng@utmb.edu
Status	Not yet recruiting
Phase	N/A
Start date	May 1, 2024
Completion date	August 31, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05104645` - Analysis of the Psychometric Properties of Kinematic Parameters of Locomotion Measured by Inertial Units. Validation in Healthy Volunteers and Stroke Patients	N/A
Recruiting	`NCT05401799` - BURT Efficacy in Improving Upper Extremity Strength and Function During Post-stroke Inpatient Rehabilitation	N/A
Recruiting	`NCT04908241` - Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL-RCT)	N/A
Not yet recruiting	`NCT02431390` - Upper Limb Biofeedback Rehabilitation System (RAPAELⓇ Smart Glove Digital Treatment System) Training for Stroke Recovery	N/A
Terminated	`NCT05650606` - Inpatient Rehabilitation and Post-Discharge Outcomes With High Intensity Gait Training (HIGT) of Patients With Stroke	N/A
Active, not recruiting	`NCT05180812` - Safety and Feasibility of ExoNET	N/A
Completed	`NCT01807637` - Transcranial Direct Current Stimulation for Improving Gait Training in Stroke	N/A
Completed	`NCT03067818` - Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis	N/A
Enrolling by invitation	`NCT03986320` - Evaluation of the Effectiveness and Safety of Keeogo™ Dermoskeleton in Subjects With Mobility Impairments Due to Stroke	N/A
Completed	`NCT04246385` - Implementing a CO-OP Group in the Day Rehab Setting: A Pilot Study.	N/A
Recruiting	`NCT03318432` - Stroke Recovery Initiative - Registry for Stroke Research Studies
Recruiting	`NCT03934073` - Evaluation of the Benefit of the Training of the Manual Dexterity Post Stroke.	N/A
Completed	`NCT01947413` - New Protocols in the Treatment of Upper Limb Dysfunctions of Patients With Stroke.	N/A
Recruiting	`NCT03350087` - Efficacy of rTMS and VCT on Upper Limb Function in Patients With Stroke	N/A
Recruiting	`NCT02996721` - A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Brain Stimulation Enhance Post-stroke Walking Survivors and Healthy Adults

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms