Cerebral Stroke Clinical Trial
Official title:
Compensatory Kinematic Movement for Reaching Task in Various Directions in After Stroke
This is cross-sectional study. By comparing kinematic analysis between stroke and healthy subjects in various directions, this investigation analyzes the compensatory kinematic movement for reaching task in stroke survivors
Status | Recruiting |
Enrollment | 96 |
Est. completion date | August 10, 2023 |
Est. primary completion date | June 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 85 Years |
Eligibility | Inclusion Criteria: The inclusion criteria used in the randomized controlled trials were as follows: Stroke - Subject consisted of the physician's confirmation of chronic hemiplegia - onset = 6 months - Mini-mental state examination=25 - Biceps =2, Triceps=2 - Ability to Sit on a chair alone - FMA upper extremity score = 21 points, FMA upper extremity = 66 points Healthy - Age of matching the stroke group - Absence of neurological disease and orthopedic disease Exclusion Criteria: Stroke - Biceps>2, Triceps>2 - Flaccid - Neglect syndrome - Have neurological disease and orthopedic disease - Lack of coordination |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Ulsan National Institute of Science and Technology | Ulsan | Ulju |
Lead Sponsor | Collaborator |
---|---|
University of Valencia | Ulsan National Institute of Science and Technology |
Korea, Republic of,
Adamovich SV, Archambault PS, Ghafouri M, Levin MF, Poizner H, Feldman AG. Hand trajectory invariance in reaching movements involving the trunk. Exp Brain Res. 2001 Jun;138(3):288-303. doi: 10.1007/s002210100694. — View Citation
Alt Murphy M, Murphy S, Persson HC, Bergstrom UB, Sunnerhagen KS. Kinematic Analysis Using 3D Motion Capture of Drinking Task in People With and Without Upper-extremity Impairments. J Vis Exp. 2018 Mar 28;(133):57228. doi: 10.3791/57228. — View Citation
Cirstea MC, Levin MF. Compensatory strategies for reaching in stroke. Brain. 2000 May;123 ( Pt 5):940-53. doi: 10.1093/brain/123.5.940. — View Citation
Cirstea MC, Mitnitski AB, Feldman AG, Levin MF. Interjoint coordination dynamics during reaching in stroke. Exp Brain Res. 2003 Aug;151(3):289-300. doi: 10.1007/s00221-003-1438-0. Epub 2003 Jun 19. — View Citation
Dean C, Shepherd R, Adams R. Sitting balance I: trunk-arm coordination and the contribution of the lower limbs during self-paced reaching in sitting. Gait Posture. 1999 Oct;10(2):135-46. doi: 10.1016/s0966-6362(99)00026-0. — View Citation
Dean CM, Shepherd RB. Task-related training improves performance of seated reaching tasks after stroke. A randomized controlled trial. Stroke. 1997 Apr;28(4):722-8. doi: 10.1161/01.str.28.4.722. — View Citation
Hsieh YW, Liing RJ, Lin KC, Wu CY, Liou TH, Lin JC, Hung JW. Sequencing bilateral robot-assisted arm therapy and constraint-induced therapy improves reach to press and trunk kinematics in patients with stroke. J Neuroeng Rehabil. 2016 Mar 22;13:31. doi: 10.1186/s12984-016-0138-5. — View Citation
Levin MF, Michaelsen SM, Cirstea CM, Roby-Brami A. Use of the trunk for reaching targets placed within and beyond the reach in adult hemiparesis. Exp Brain Res. 2002 Mar;143(2):171-80. doi: 10.1007/s00221-001-0976-6. Epub 2002 Jan 8. — View Citation
Lobo-Prat J, Font-Llagunes JM, Gomez-Perez C, Medina-Casanovas J, Angulo-Barroso RM. New biomechanical model for clinical evaluation of the upper extremity motion in subjects with neurological disorders: an application case. Comput Methods Biomech Biomed — View Citation
Machado LR, Heathcock J, Carvalho RP, Pereira ND, Tudella E. Kinematic characteristics of arm and trunk when drinking from a glass in children with and without cerebral palsy. Clin Biomech (Bristol, Avon). 2019 Mar;63:201-206. doi: 10.1016/j.clinbiomech.2019.03.011. Epub 2019 Mar 19. — View Citation
Schwarz A, Veerbeek JM, Held JPO, Buurke JH, Luft AR. Measures of Interjoint Coordination Post-stroke Across Different Upper Limb Movement Tasks. Front Bioeng Biotechnol. 2021 Jan 28;8:620805. doi: 10.3389/fbioe.2020.620805. eCollection 2020. — View Citation
Thrane G, Sunnerhagen KS, Murphy MA. Upper limb kinematics during the first year after stroke: the stroke arm longitudinal study at the University of Gothenburg (SALGOT). J Neuroeng Rehabil. 2020 Jun 15;17(1):76. doi: 10.1186/s12984-020-00705-2. — View Citation
Wu CY, Liing RJ, Chen HC, Chen CL, Lin KC. Arm and trunk movement kinematics during seated reaching within and beyond arm's length in people with stroke: a validity study. Phys Ther. 2014 Jun;94(6):845-56. doi: 10.2522/ptj.20130101. Epub 2014 Jan 30. — View Citation
* Note: There are 13 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Modified Ashworth Scale_Stiffness of chronic stroke | Scoring for Biceps and Triceps
MAS 0: No increase in tone MAS 1: slight increase in tone giving a catch when slight increase in muscle t-tone, manifested by the limb was moved in flexion or extension. MAS 1+: slight increase in muscle tone, manifested by a catch followed by minimal resistance throughout (ROM ) MAS 2: more marked increase in tone but more marked increased in muscle tone through most limb easily flexed MAS 3: considerable increase in tone, passive movement difficult MAS 4: limb rigid in flexion or extension |
1 time(Baseline) | |
Other | Range of motion_Health status chronic stroke | Shoulder and elbow joint range of motion
Shoulder flexion, adduction, abduction, external rotation, internal rotation Elbow flexion, extension |
1 time(Baseline) | |
Other | Trunk impairment scale(TIS)_Health status chronic stroke | Static sitting balance
Dynamic sitting balance Coordination Total score is 23 points |
1 time(Baseline) | |
Other | Postural assessment scale for stroke(PASS)_Health status chronic stroke | Maintaining posture
Sitting without support Standing with support Standing without support Standing on non paretic leg Standing on paretic leg Changing a posture 6.Supine to paretic side lateral 7.Supine to non-paretic side lateral 8.Supine to sitting up on the edge mat 9.Sitting on the edge of mat to supine 10.Sitting to standing up 11.Standing up to sitting down 12.Standing, picking up a pencil from the floor Total score is 36 points |
1 time(Baseline) | |
Other | Fugl_Meyer Assessment(FMA)_Health status chronic stroke | Upper extremity
Shoulder, Elbow and Forearm Reflex activity Volitional movement within synergies Volitional movement mixing synergies Volitional movement with little or no synergy Normal reflex activity Wrist Hand Coordination/Speed Total score is 66 points |
1 time(Baseline) | |
Primary | Difference of the components temporal measurements between healthy and stroke | Hand velocity(peak velocity of 3th metacarpal phalangeal joint marker in reaching phase in millimetres per second; mm/s),total movement time in second, reaching time in second, number of movement units. elbow angular acceleration(elbow angular velocity per unit time; rad/sec2) and elbow angular velocity(time rate at which an object rotates, or revolves, about an axis, or at which the angular displacement between two forearm and humerus; rad/s) in reaching 3 directions(medial_45, forward_90 and lateral_135 degrees).
Participants reach to a bell as quickly as possible. 3th joint is calculated for quantitative measurements. |
1 time(Baseline) | |
Primary | Difference of the components spatial measurements between healthy and stroke | Trunk dislocation of reaching phase in millimetre; mm), elbow and shoulder angle in reaching in degree. The measurements are detected by 3 directions(medial_45, forward_90 and lateral_135 degrees).
Participants reach to a bell as quickly as possible. 3th joint is calculated for quantitative measurements. |
1 time(Baseline) | |
Secondary | Relationship between clinical score and kinematic variable in each direction | Related FMA score(dependent) to predictors(independent) in three directions. | 1 time(Baseline) |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
|
||
Recruiting |
NCT03685578 -
CERENOVUS Neurothrombectomy Devices Registry
|
||
Recruiting |
NCT05591183 -
CERENOVUS Neurothrombectomy Devices Registry
|
||
Completed |
NCT04465019 -
Exoskeleton Rehabilitation on TBI
|
||
Completed |
NCT02827825 -
Patients Undergoing Strokes Admitted in Intensive Care Requiring Neurosurgical ICU Crossing: Patient Profile and Prognosis
|
||
Recruiting |
NCT02077582 -
Longitudinal MRI Examinations of Patients With Brain Ischemia and Blood Brain Barrier Permeability
|
N/A | |
Terminated |
NCT01705353 -
The Role of HMGB-1 in Chronic Stroke
|
N/A | |
Completed |
NCT01732679 -
Sunnaas International Network´s Stroke Study
|
N/A | |
Completed |
NCT01182818 -
Fabry and Stroke Epidemiological Protocol (FASEP): Risk Factors In Ischemic Stroke Patients With Fabry Disease
|
N/A | |
Completed |
NCT00311025 -
Stroke: Reduction of Physical Performance Post Stroke. Inactivity or Secondary Complications?
|
Phase 1/Phase 2 | |
Withdrawn |
NCT03804125 -
A Study of Adverse Events and Suspected Adverse Drug Reactions in Patients Under Apixaban for Prevention of Stroke and Systemic Embolism With Non-Valvular Atrial Fibrillation and Venous Thromboembolic Events in Patients Who Have Undergone Elective Hip or Knee Replacement Surgery
|
||
Completed |
NCT05435404 -
Qualitative Study Patient & Physician Experiences Botox COVID-19
|
||
Completed |
NCT03898960 -
Post Marketing Study to Evaluate the NIMBUS Device
|
||
Not yet recruiting |
NCT06087094 -
A Trial of HRS-7450 in Chinese Healthy Volunteers
|
Phase 1 | |
Completed |
NCT02207023 -
Healthy Lifestyles After Stroke - Stroke Coach
|
N/A | |
Active, not recruiting |
NCT02017574 -
Motor Learning in Stroke
|
Phase 0 | |
Completed |
NCT01864382 -
"Core Stability" Exercises to Improve Sitting Balance in Stroke Patients
|
N/A | |
Completed |
NCT02002390 -
Efficacy and Safety of FTY720 for Acute Stroke
|
Phase 2 | |
Recruiting |
NCT04447599 -
Conjunctival and Retinal Vascularization and Small Vessel Disease
|
N/A | |
Recruiting |
NCT04157179 -
Cerebral Oxygen Metabolism in Children
|
N/A |