Clinical Trials Logo

Clinical Trial Summary

It is estimated that 2 out of 3 patients with a stroke have some problems with their memory, difficulties performing certain tasks, making decisions and learning new things. In addition, many stroke patients do not get regular exercise and are often sedentary. Both physical and cognitive exercise have the potential to improve quality of life, cognition, and overall health, but the safety and tolerability of such interventions is not clear in stroke patients. The investigators will examine these outcomes by allocating stroke survivor participants to one of two groups: a combined exercise and cognitive training program and a sham control group.


Clinical Trial Description

Stroke is well recognized as the leading cause of disability in the United States. Cognitive deficits after stroke are common, even in those without dementia prior to the event, and stroke patients with worse cognition on hospital admission have worse outcomes. Cognitive deficits contribute to stroke-related disability and mortality. Evidence suggests an interaction between cognitive deficits and physical limitations, and cognitive rehabilitation may improve functional outcomes post stroke. Recent data also suggest that both cognitive training and exercise interventions improve cognition in stroke patients, but few randomized trials of these interventions, alone or in combination, have been conducted.

We will study the effects of a Combined Aerobic and Resistance Exercise Training (CARET) program and CTI interventions on the primary outcome of safety, feasibility, and adherence among ischemic or hemorrhagic stroke survivors with mild to moderate disability. We hypothesize that these interventions are safe and tolerable, and that they will lead to improvements in our secondary outcomes of cognitive performance and quality of life. We will also explore the role of Brain Derived Neurotrophic Factor in cognitive changes related to the physical exercise intervention. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02272426
Study type Interventional
Source University of Miami
Contact
Status Completed
Phase N/A
Start date November 2014
Completion date March 20, 2019

See also
  Status Clinical Trial Phase
Completed NCT03281590 - Stroke and Cerebrovascular Diseases Registry
Recruiting NCT03685578 - CERENOVUS Neurothrombectomy Devices Registry
Recruiting NCT05591183 - CERENOVUS Neurothrombectomy Devices Registry
Completed NCT04465019 - Exoskeleton Rehabilitation on TBI
Completed NCT02827825 - Patients Undergoing Strokes Admitted in Intensive Care Requiring Neurosurgical ICU Crossing: Patient Profile and Prognosis
Recruiting NCT02077582 - Longitudinal MRI Examinations of Patients With Brain Ischemia and Blood Brain Barrier Permeability N/A
Terminated NCT01705353 - The Role of HMGB-1 in Chronic Stroke N/A
Completed NCT01732679 - Sunnaas International Network´s Stroke Study N/A
Completed NCT01182818 - Fabry and Stroke Epidemiological Protocol (FASEP): Risk Factors In Ischemic Stroke Patients With Fabry Disease N/A
Completed NCT00311025 - Stroke: Reduction of Physical Performance Post Stroke. Inactivity or Secondary Complications? Phase 1/Phase 2
Withdrawn NCT03804125 - A Study of Adverse Events and Suspected Adverse Drug Reactions in Patients Under Apixaban for Prevention of Stroke and Systemic Embolism With Non-Valvular Atrial Fibrillation and Venous Thromboembolic Events in Patients Who Have Undergone Elective Hip or Knee Replacement Surgery
Completed NCT05435404 - Qualitative Study Patient & Physician Experiences Botox COVID-19
Completed NCT03898960 - Post Marketing Study to Evaluate the NIMBUS Device
Not yet recruiting NCT06087094 - A Trial of HRS-7450 in Chinese Healthy Volunteers Phase 1
Completed NCT02207023 - Healthy Lifestyles After Stroke - Stroke Coach N/A
Active, not recruiting NCT02017574 - Motor Learning in Stroke Phase 0
Completed NCT02002390 - Efficacy and Safety of FTY720 for Acute Stroke Phase 2
Completed NCT01864382 - "Core Stability" Exercises to Improve Sitting Balance in Stroke Patients N/A
Recruiting NCT04447599 - Conjunctival and Retinal Vascularization and Small Vessel Disease N/A
Recruiting NCT04157179 - Cerebral Oxygen Metabolism in Children N/A