Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT06180395 |
| Other study ID # |
CairoU_STE |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
January 10, 2024 |
| Est. completion date |
April 2024 |
Study information
| Verified date |
March 2024 |
| Source |
Cairo University |
| Contact |
Shimaa Talaat Emara |
| Phone |
01060279269 |
| Email |
shimaaemara2015[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
studying the relationship between Bone Mineral Density, Gross Motor Function and, Quality of
Life with CP can provide valuable insights into the musculoskeletal consequences of motor
impairments and guide interventions to improve bone health.
Statement of the problem Is there a relation between Bone Mineral Density, Gross Motor
Function and Quality of Life in children with CP ? Purpose of the study
To study the relationship between:
1. Bone Mineral Density and Gross Motor Function in ambulant and non-ambulant CP children.
2. Bone Mineral Density and Quality of Life in ambulant and non-ambulant CP children.
3. Gross Motor Function and Quality of Life in ambulant and non-ambulant CP children.
Description:
Cerebral palsy (CP) is primarily a neuromotor disorder that affects the development of
movement, muscle tone and posture. The underlying pathophysiology is an injury to the
developing brain in the prenatal through neonatal period. Although the initial neuro
pathologic lesion is non-progressive, children with cerebral palsy may develop a range of
secondary conditions over time that will variably affect their functional abilities. The
prevalence of CP varies between 1.5 to more than 4 cases per 1,000 live births worldwide. The
motor impairments associated with CP can range from mild to severe, affecting different
muscle groups and leading to difficulties in activities of daily living and participation in
social and recreational activities.
Children with CP often experience motor impairments that affect their gross motor function,
leading to limitations in activities and participation. These motor impairments can also have
a negative impact on bone health, resulting in reduced bone mineral density (BMD) and
increased risk of skeletal complications.
Gross motor function (GMF) refers to the ability to perform coordinated movements using large
muscle groups, such as walking, running, and jumping. It is a key aspect of physical ability
and independence in daily activities for children with CP. Previous research has shown that
gross motor function is closely associated with bone health in this population. However,
further investigation is needed to explore the specific nature of this correlation and its
implications for intervention strategies.
Gross motor function is commonly assessed using standardized tools such as the Gross Motor
Function Classification System (GMFCS) or the Gross Motor Function Measure (GMFM). Quality of
life is a multidimensional construct that encompasses physical, psychological, and social
well-being. In the context of cerebral palsy, understanding the impact of gross motor
function on quality of life is crucial for comprehensive care and intervention planning.
Children with CP may face limitations in mobility, participation in activities, and social
interactions, which can significantly affect their overall quality of life. Exploring the
relationship between gross motor function and quality of life can provide valuable insights
into the factors influencing the holistic well-being of children with CP.
The quality of life in children with CP is not only influenced by their motor function but
also by their overall health and well-being. Bone health plays a crucial role in maintaining
the physical abilities and independence of individuals, as well as their overall quality of
life. Impaired bone health in children with CP can lead to limitations in mobility, increased
pain, and reduced participation in activities, which can have a significant impact on their
overall well-being.
Bone mineral density, on the other hand, is an important measure of bone strength and overall
skeletal health. Children with CP often exhibit lower BMD compared to typically developing
peers due to factors such as reduced weight-bearing activities, muscle weakness, altered
biomechanics, limited mobility, and hormonal imbalances. This reduced BMD increases their
susceptibility to fractures and skeletal deformities, further impacting their functional
abilities and quality of life.
