Cerebral Palsy Clinical Trial
Official title:
Tracking General Movements: An Observing-the-Observer Approach to Enhance Clinical Reasoning
Background: General movements (GMs) are endogenously generated movements of the entire body
observable from the 9th week postmenstrual age to at least 20 weeks postterm age. The
assessment of GMs, the GMA, is a method to differentiate between spontaneous normal vs.
abnormal motor patterns based on visual Gestalt perception, and has proven to be a reliable
tool to evaluate the integrity of the nervous system in early infancy. Trained GMA observers
achieve an excellent inter-observer agreement, but this accuracy is known to decline when GMA
is applied infrequently. Although specific changes in the quality of GMs are highly
predictive for atypical neurodevelopmental trajectories, one pattern of GMs, the
poor-repertoire, is still of low predictive power.
Objectives: Tracking GMA observers' intrinsic and unconsciously applied analytic strategies
may unravel hitherto unknown characteristics of GMs and Gestalt perception in clinical
reasoning. We specifically aim to: detect parameters during the writhing movements period
which differentiate normalising and deteriorating developmental trajectories (Aim 1);
evaluate different strategies/modalities of expert guidance for clinical reasoning and
develop novel didactical approaches for remote GMA training (remote visual and verbal
guidance; Aim 2); create a database to provide expert-guided tutorials for remote clinical
training, observer re-calibration, and self-evaluation for certified observers (Aim 3).
Approach / methods: Based on our expertise in GMA and eye tracking, and a successful proof of
principle (pilot experiment), we will conduct a series of experiments: GMA experts' eye
movement patterns during clinical reasoning will be assessed to better understand the
diagnostic category of poor-repertoire GMs (Experiment 1); benefits and potential
difficulties of different modes of "seeing through the eyes of an expert"-approaches for
GMA-training will be explored (Experiment 2); we shall evaluate enhancement of clinical
reasoning as a result of intensive remote GMA training (Experiment 3).
Level of originality / innovation: "Tracking general movements" will (1) contribute to better
understand poor-repertoire GMs adding to the clinical necessity to closely follow infants in
need for continuous or close-meshed clinical surveillance; (2) define the benefits of
different modes/modalities of expert guidance for GMA, which will form the basis for
innovative remote clinical GMA training; and (3) create a globally accessible database for
remote clinical GMA refreshment-training and re-calibration.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05317234 -
Genetic Predisposition in Cerebral Palsy
|
N/A | |
Recruiting |
NCT05576948 -
Natural History of Cerebral Palsy Prospective Study
|
||
Completed |
NCT04119063 -
Evaluating Wearable Robotic Assistance on Gait
|
Early Phase 1 | |
Completed |
NCT03264339 -
The Small Step Program - Early Intervention for Children With High Risk of Developing Cerebral Palsy
|
N/A | |
Completed |
NCT05551364 -
Usability and Effectiveness of the ATLAS2030 Exoskeleton in Children With Cerebral Palsy
|
N/A | |
Completed |
NCT03902886 -
Independent Walking Onset of Children With Cerebral Palsy
|
||
Recruiting |
NCT05571033 -
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
|
N/A | |
Not yet recruiting |
NCT04081675 -
Compliance in Children With Cerebral Palsy Supplied With AFOs
|
||
Completed |
NCT02167022 -
Intense Physiotherapies to Improve Function in Young Children With Cerebral Palsy
|
N/A | |
Completed |
NCT04012125 -
The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy
|
N/A | |
Enrolling by invitation |
NCT05619211 -
Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities
|
Phase 1 | |
Completed |
NCT04489498 -
Comparison of Somatometric Characteristics Between Cerebral Palsy and Normal Children, Cross-sectional, Multi Center Study
|
||
Completed |
NCT03677193 -
Biofeedback-enhanced Interactive Computer-play for Youth With Cerebral Palsy
|
N/A | |
Recruiting |
NCT06450158 -
Robot-assisted Training in Children With CP
|
N/A | |
Completed |
NCT04093180 -
Intensive Neurorehabilitation for Cerebral Palsy
|
N/A | |
Completed |
NCT02909127 -
The Pediatric Eating Assessment Tool
|
||
Not yet recruiting |
NCT06377982 -
Human Umbilical Cord Blood Infusion in Patients With Cerebral Palsy
|
Phase 1 | |
Not yet recruiting |
NCT06007885 -
Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
|
N/A | |
Not yet recruiting |
NCT03183427 -
Corpus Callosum Size in Patients With Pineal Cyst
|
N/A | |
Active, not recruiting |
NCT03078621 -
Bone Marrow-Derived Stem Cell Transplantation for the Treatment of Cerebral Palsy
|
Phase 1/Phase 2 |