Cerebral Palsy Clinical Trial
Official title:
Integrated Management With Brain Stimulation and Hybrid Training Enhances Functional Gains in Children With Cerebral Palsy Treated by Botulinum Toxin A
Evidence from literature support the use of Botulinum toxin A (BoNT-A) for upper limb
spasticity management in children with cerebral palsy (CP). Constraint Induced Movement
Therapy (CIMT) and Bilateral Intensive Training (BIT) are indicated as effective and
complimentary treatments to improve motor function in these children. In a recent trial
combined noninvasiv brain stimulation and CIMT enhanced therapy induced functional gains.
In this clinical trial the aim was to evaluate the effects of transcranial direct current
stimulation (t-DCS) plus intensive hybrid training model of modified CIMT and BIT when
integrated with BoNT-A treatment in children with unilateral CP.
Although BoNT-A is effective in spasticity management there is inconclusive evidence to support its usage for improvement in upper limb activity and function. Combination of BoNT-A and occupational therapy (OT) is found to be more effective then OT alone in reducing impairment, improving activity level and goal achievement. Intensive hybrid training models of CIMT and BIT and noninvasive brain stimulation are promising treatments on motor learning in children with CP. The aim of this clinical trial is to show the additional gains that could be provided by an integrated treatment of transcranial direct current stimulation (t-DCS) plus intensive hybrid training model of modified CIMT and BIT to BoNT-A injections in children with unilateral CP. ;
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