Corpus Callosum Size in Patients With Pineal Cyst

Cerebral Palsy Clinical Trial

Official title:

Corpus Callosum Size in Patients With Pineal Cyst

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03183427
• Other study ID #: 108/11-28/2017
• Status: Not yet recruiting
• Phase: N/A
• First received: June 8, 2017
• Last updated: June 10, 2017
• Start date: September 2017
• Est. completion date: September 2018

Study information

• Verified date: June 2017
• Source: Military University Hospital, Prague
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aims to determine size of corpus callosum on midsagittal MR scan in patients with a pineal cyst and to compare it with the control group without a pineal cyst.

Description:

A pineal cyst (PC) is a benign affection of the pineal gland, its prevalence in population reaches 1-2 %. Etiopathogenesis of PC is unknown, several hypotheses have been proposed. One of the hypothesis consider perinatal hypoxia as a causative factor for a development of PC in later life. Ozmen et al. showed significantly higher prevalence of PC in patients with cerebral palsy (p<0.001). Bregant et al. studied presence of PC in patients that suffered from a mild to moderate perinatal hypoxia. Prevalence of PC reached 36 % in these patients and presence of PC was associated with a atrophy of the corpus callosum (p<0.005). The atrophy of the corpus callosum is considered to be a sign of a periventricular leukomalacia, i.e. an ischemic insult in a perinatal period.

In the present study, we are going to compare an area of corpus callosum on a midsagittal magnetic resonance T2-weighted scan in the group of patients with PC and in the control group without PC. The goal of the study is to determine if there is a relationship between atrophy of the corpus callosum and PC. Such finding would support abovementioned theory of etiopathogenesis of PC.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 200
• Est. completion date: September 2018
• Est. primary completion date: January 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• 3T MR examination of the brain including T2 sagittal scans

Exclusion Criteria:

• other intracranial pathology discovered on the MR

• other known neurological disease (e.g. multiple sclerosis, stroke, tumor, etc.)

Related Conditions & MeSH terms

• Atrophy
• Cerebral Palsy
• Corpus Callosum Atrophy
• Pineal Gland Disorder

Intervention

Diagnostic Test:
• MR of the brain
MR of the brain without gadolinium, incl. T2-weighted image

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Military University Hospital, Prague

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	size of corpus callosum	size of corpus callosum in mm2 measured on the midsagittal T2-weighted MR scan	time of the MR examination