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Stem Cells in Umbilical Blood Infusion for CP — SCUBI-CP  

Cerebral Palsy Clinical Trial

Official title:
Safety Study of Sibling Cord Blood Cell Infusion to Children With Cerebral Palsy

Clinical Trial Summary

This study will investigate the safety of single dose intravenous infusion of cord blood cells which were cryopreserved after the birth of a brother or sister to a child with cerebral palsy.

Clinical Trial Description

Cerebral palsy (CP) is the most common physical disability of childhood, affecting 2 per 1000 live births across the world. CP describes permanent non-progressive motor disorders arising from damage to the developing brain. Preclinical studies of different types of stem cells in models of acute brain injury similar to CP have shown significant functional improvement. The variety of stem cells available in umbilical cord blood (UCB), an ethically uncomplicated source of stem cells, has led to a focus on UCB stem cell therapy as a quick-to-clinic option. Previous studies indicate that autologous or unrelated donor UCBC infusion is safe and feasible for children with CP, and may lead to improved motor functioning, but there is no information about the safety and effects of matched sibling cord blood. Therefore, this trial will study the safety of infusing matched sibling cord blood cells to children with cerebral palsy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03087110
Study type Interventional
Source Murdoch Childrens Research Institute
Contact
Status Completed
Phase Phase 1
Start date March 2016
Completion date December 2020
View Details
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