Cerebral Palsy Clinical Trial
Official title:
Upper Extremity Strength in Children and Adolescents With and Without Unilateral Cerebral Palsy
Rationale:
Children with Cerebral Palsy (CP) experience limitations in motor activities and
participation in the community, predominantly caused by impairments in muscle function. Aside
from abnormal posturing due to spasticity, muscle weakness can significantly contribute to
impaired muscle function and there is increasing evidence that muscle weakness significantly
impairs upper limb motor function and ability to perform manual tasks in children with CP.
Studies in the last decade have shown that muscle weakness, not spasticity, is the greatest
limiting factor of motor function in children with CP. Furthermore, there is increasing
evidence that the strength in the upper extremities of children with CP is less compared to
their typically developing peers (TDP). A systematic review focused on the psychometric
properties of strength measurement instruments has shown that the number of studies
investigating psychometric properties of strength measurement instruments is limited and that
the methodological quality of these studies is low.
Aim:
The present study aims to investigate the reproducibility of the following three isometric
strength measurements in the upper extremity of children and adolescents with unilateral CP
as well as in TDP: Hand Held Dynamometry (HHD), pinch and grip strength using the E-link
system and functional strength. To study to which extent upper extremity strength, both in
the affected side and the non-affected side, differs from the strength in the upper
extremities of TDP, these measurements will also be performed by children without
neurological problems.
Study Design:
A cross-sectional study in which the reproducibility of three strength measurement
instruments, i.e. HHD, E-link and Functional strength, will be investigated in children and
adolescents with unilateral CP and TDP.
Population:
Children with unilateral spastic CP (with perinatal acquired hypoxic ischemic incidents),
aged 7 to 18 years, Manual Ability Classification System (MACS) levels I-III, who are
mentally able to perform the measurements will be included and TDP.
Outcome measures:
The most important psychometric property in strength measurement instruments is
reproducibility. Reproducibility will be investigated using the following factors: Intraclass
Correlation Coefficient (ICC), Limits of Agreement (LOA), Standard Error of Measurement (SEM)
and the Smallest Detectable Difference (SDD). Reference values will be determined using the
Generalised Additive Models for Location, Scale, and Shape (GAMLSS) method.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05317234 -
Genetic Predisposition in Cerebral Palsy
|
N/A | |
Recruiting |
NCT05576948 -
Natural History of Cerebral Palsy Prospective Study
|
||
Completed |
NCT04119063 -
Evaluating Wearable Robotic Assistance on Gait
|
Early Phase 1 | |
Completed |
NCT03264339 -
The Small Step Program - Early Intervention for Children With High Risk of Developing Cerebral Palsy
|
N/A | |
Completed |
NCT05551364 -
Usability and Effectiveness of the ATLAS2030 Exoskeleton in Children With Cerebral Palsy
|
N/A | |
Completed |
NCT03902886 -
Independent Walking Onset of Children With Cerebral Palsy
|
||
Recruiting |
NCT05571033 -
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
|
N/A | |
Not yet recruiting |
NCT04081675 -
Compliance in Children With Cerebral Palsy Supplied With AFOs
|
||
Completed |
NCT02167022 -
Intense Physiotherapies to Improve Function in Young Children With Cerebral Palsy
|
N/A | |
Completed |
NCT04012125 -
The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy
|
N/A | |
Enrolling by invitation |
NCT05619211 -
Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities
|
Phase 1 | |
Completed |
NCT04489498 -
Comparison of Somatometric Characteristics Between Cerebral Palsy and Normal Children, Cross-sectional, Multi Center Study
|
||
Completed |
NCT03677193 -
Biofeedback-enhanced Interactive Computer-play for Youth With Cerebral Palsy
|
N/A | |
Recruiting |
NCT06450158 -
Robot-assisted Training in Children With CP
|
N/A | |
Completed |
NCT04093180 -
Intensive Neurorehabilitation for Cerebral Palsy
|
N/A | |
Completed |
NCT02909127 -
The Pediatric Eating Assessment Tool
|
||
Not yet recruiting |
NCT06377982 -
Human Umbilical Cord Blood Infusion in Patients With Cerebral Palsy
|
Phase 1 | |
Not yet recruiting |
NCT06007885 -
Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
|
N/A | |
Not yet recruiting |
NCT03183427 -
Corpus Callosum Size in Patients With Pineal Cyst
|
N/A | |
Active, not recruiting |
NCT03078621 -
Bone Marrow-Derived Stem Cell Transplantation for the Treatment of Cerebral Palsy
|
Phase 1/Phase 2 |