Cerebral Palsy Clinical Trial
Official title:
A Longitudinal Study of Movement and Participation in Patients With Cerebral Palsy: a Combined Brain Imaging and Kinematic Analysis
The primary goal of this study is to establish and evaluate an image-based biomarker for the impaired motor control and sensory information processing present in Cerebral palsy (CP) patients
Cerebral palsy (CP) may lead to various motor deficits, which further influence the
activities and participation. It would be ideal to characterize neural network and motor
control model in patients with CP that underlies their clinical behavior by identifying
altered neural network and motor control associated with behavioral improvement. The aim of
this study is to investigate the brain image and motor control in patients with CP evaluated
by multimodal imaging studies utilizing multi-modal techniques and kinematic analysis.
This study includes a prospective longitudinal study of patients with CP over one-year. This
study will be executed in 3 phases within 3 years: 1st phase (1st years): to establish the
multimodal brain images and motor control, and clinical outcomes protocol with a prospective
one-year follow-up study in healthy subjects; 2nd phase (2nd years): to establish the brain
images and motor control, and clinical outcomes with a prospective one-year follow-up study
in older patients with CP; and 3rd phase (3rd years): to establish the brain images and motor
control, and clinical outcomes with a prospective one-year follow-up study in younger
patients with CP. In a prospective longitudinal study, each participant received 3-times
measurements: at the beginning, 6 months later, and one year after the first data collection
point
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