Cerebral Palsy Clinical Trial
Official title:
The Safety of Multiple Intrathecal Injection of Bone Marrow Derived CD133 Cells in Patients With Cerebral Palsy
Cerebral palsy (CP) is condition, sometimes thought of as a group of disorders that can
involve brain and nervous system functions such as movement, learning, hearing, seeing, and
thinking.Cerebral palsy is caused by injuries or abnormalities of the brain. Most of these
problems occur as the baby grows in the womb, but they can happen at any time during the
first 2 years of life, while the baby's brain is still developing.Bone marrow derived stem
cells are known as a effective therapy.
In this study the investigators evaluate the side effect of multiple intrathecal injection
of bone marrow stem cell in patients with cerebral palsy.
In this study,we evaluate the safety of multiple transplantation of bone marrow derived stem cells.the children(4-12years)with definite diagnose of cerebral palsy enroll to the study.first of all all the physical exam,laboratory test,EEG and MRI is done.after hospital admission,the patient underwent bone marrow transplantation.In laboratory,the cells are separated and prepared for injection.after 24hours the neurosurgeon inject the cells(intrathecal).the patient would be under observed for 48hours.If no allergic reaction or abnormal neurological symptoms accrued,patients can be discharged and would be followed up 1,3 and 6months after injection.at the end of the 6months,the patients would receive second injection as same as the previous process.then they are followed at 1,3 immediate local and systemic side effect(fever,respiratory distress,erythema,rash,increase of heart rate or blood pressure)and neurological symptoms:motor dysfunction,sensory dysfunction,sphincter dysfunction,nausea,vomiting,head ache.EEG,MRI,GMFM66 ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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