Cerebral Palsy Clinical Trial
Official title:
The Relationship of Bone Strength and Fitness Training in Children With Cerebral Palsy
In the first year, all subjects received clinical assessments include subjective assessment,
basic data, nutritional status and fitness assessments. Laboratory assessments include body
composition, bone density(lumbar spine and femur by dual energy X-ray absorptiometry ), bone
strength (by calcaneal ultrasound) and bone metabolism.
In the 2nd year, were randomized into three groups. The high level training group (20
children) will receive high frequency fitness training program(Frequency: three times one
week, Duration: thirty minutes). The low level training group (20 children) will receive low
frequency fitness training program(Frequency: two times one week, Duration: thirty
minutes).The control group (20 children) will not receive fitness training program but
maintain the usual life style.
In the 3rd year, all subjects received post-training clinical assessments include subjective
assessment, basic data, nutritional status and fitness assessments. Laboratory assessments
include body composition, bone density(lumbar spine and femur by dual energy X-ray
absorptiometry ), bone strength (by calcaneal ultrasound) and bone metabolism.
These data provided in this study could establish the bone quality and fitness data of
children with diplegic CP, and provide us to plan treatment strategies in the management of
bone and fitness problems in the future.
Malnutrition and motor impairment are common in children with cerebral palsy. Poor nutrition
and motor impairment may further contribute to fitness impairment, low bone mineralization
density (BMD), low bone strength, and even fractures in children with CP. To management of
bone problems is based on the understanding the pathophysiology of bone mineralization or
bone strength in CP.
Multiple factors, including nutritional factors (eg. nutritional status, body composition)
and non-nutritional factors (eg. fitness, immobility, use of anticonvulsants) that may
potentially have an impact on bone density/strength in children with CP However, there were
few studies to investigate the relationship of bone strength and fitness in children with
cerebral palsy in Taiwan. We hypothesized that fitness training may potentially have an
impact on bone density/strength in children with CP. The purpose of this study is to further
find out the relationship of bone quality and fitness training in children with CP.
We will collect 60 children with diplegic CP. The inclusion criteria include good cognition
to comprehend the command and cooperation during examination and fitness training. The
exclusion criteria were following as chromosomal abnormalities, active medical conditions
such as pneumonia or others, poor tolerance during assessment and fitness training.
In the first year, all subjects received clinical assessments include subjective assessment,
basic data, nutritional status and fitness assessments. Laboratory assessments include body
composition, bone density(lumbar spine and femur by dual energy X-ray absorptiometry ), bone
strength (by calcaneal ultrasound) and bone metabolism.
In the 2nd year, were randomized into three groups. The high level training group (20
children) will receive high frequency fitness training program(Frequency:three times one
week, Duration: 40 minutes).The low level training group (20 children) will receive low
frequency fitness training program(Frequency: 1-2 times one week, Duration: 40 minutes). The
control group (20 children) will not receive fitness training program but maintain the usual
life style.
In the 3rd year, all subjects received post-training clinical assessments include subjective
assessment, basic data, nutritional status and fitness assessments. Laboratory assessments
include body composition, bone density(lumbar spine and femur by dual energy X-ray
absorptiometry ), bone strength (by calcaneal ultrasound) and bone metabolism.
These data provided in this study could establish the bone quality and fitness data of
children with diplegic CP, and provide us to plan treatment strategies in the management of
bone and fitness problems in the future.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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