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Intrathecal Stem Cells in Brain Injury — ISC  

Cerebral Palsy Clinical Trial

Official title:
Intrathecal Autologous Stem Cells for Children With Hipoxic/Ischemic Brain Injury

Clinical Trial Summary

The purpose of this study is to determine whether the plasticity of autologous intrathecal hematopoietic cells would improve the neurologic evolution of the pediatric patients with hypoxic/ischemic brain injury.

Clinical Trial Description

There is accumulating evidence that shows that the placement of hematopoietic cells in the brain may increase growth-enhancing factors of axons and generate active neurons in the receptor. It has been found that after introducing hematopoietic cells in the subarachnoid space of the spinal cord, these cells may be transported through the cerebrospinal fluid and can be deliver more efficiently to the injured area, when compared to the intravenous route. Patients will be stimulated 4 times and then harvest the bone marrow. Bone marrow will be processed in order to obtain hematopoietic cells (CD34+) and minimize the erythrocytes amount. A inoculum of 5 to 10mL of stem cells will be infused intrathecally. Patients will be evaluated with the "Battelle Developmental Inventory" before the procedure and one and six months after that. An MRI will be performed before the procedure and six months after that. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01019733
Study type Interventional
Source Hospital Universitario Dr. Jose E. Gonzalez
Contact
Status Completed
Phase N/A
Start date July 2009
Completion date January 2011
View Details
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