Cerebral Palsy Clinical Trial
Official title:
Optic Nerve Head Morphology in Children With Perinatal Onset Static Encephalopathy
Hypothesis: Children born prematurely (between 8 and 9 months) with brain damage have an
abnormal appearance of the optic nerve (nerve in eye) that resembles glaucoma (cupping)
compared to those born before 8 months.
Purpose: to see how often children who are born prematurely and have suffered brain damage,
have abnormal appearance of the optic nerve (nerve in the eye) which mimics glaucoma
(cupping). This optic nerve cupping is most often seen when children are born after 8 months
and is rarely seen in children born before 8 months.
Children born prematurely are known to have injuries to their brain as they are not yet
fully developed. This often involves the part of the brain that involves vision. Clinicians
have observed that these children have an abnormal appearance of the optic nerve (nerve in
the eye), which has the appearance of glaucoma. These children often undergo extensive and
often unnecessary invasive tests to rule out glaucoma. The investigators wish to establish
the prevalence of this abnormality so that children are not subjected to unnecessary
investigations. The investigators also want to understand how the optic nerve cupping
(similar clinical picture as glaucoma) is related to the approximate timing and extent of
the brain injury, the type of cerebral palsy and the motor disability of these children.
Status | Completed |
Enrollment | 61 |
Est. completion date | January 2009 |
Est. primary completion date | January 2009 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 17 Years |
Eligibility |
Inclusion Criteria: - Children born prematurely at age 24-36 weeks of gestation; are currently in the age group 0-17 years and enrolled in Dr Vedanarayanan's pediatric neurology clinic. - Diagnosis of static encephalopathy, cerebral palsy or CNS malformations - Availability of CT head or MRI brain for review. Exclusion Criteria: - Parents/guardians or the child refuse consent or assent. - Presence of ocular media opacities preventing visualization of the fundus - The child is unable to cooperate for the ocular examination. - Coexistent diagnosis of glaucoma - Unable to obtain perinatal history from parents/guardians or records |
Observational Model: Cohort, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
United States | University of Mississippi Medical Center | Jackson | Mississippi |
Lead Sponsor | Collaborator |
---|---|
University of Mississippi Medical Center |
United States,
Hellström A. Optic nerve morphology may reveal adverse events during prenatal and perinatal life--digital image analysis. Surv Ophthalmol. 1999 Oct;44 Suppl 1:S63-73. — View Citation
Jacobson L, Hård AL, Svensson E, Flodmark O, Hellström A. Optic disc morphology may reveal timing of insult in children with periventricular leucomalacia and/or periventricular haemorrhage. Br J Ophthalmol. 2003 Nov;87(11):1345-9. — View Citation
Jacobson L, Hellström A, Flodmark O. Large cups in normal-sized optic discs: a variant of optic nerve hypoplasia in children with periventricular leukomalacia. Arch Ophthalmol. 1997 Oct;115(10):1263-9. — View Citation
McLoone E, O'Keefe M, Donoghue V, McLoone S, Horgan N, Lanigan B. RetCam image analysis of optic disc morphology in premature infants and its relation to ischaemic brain injury. Br J Ophthalmol. 2006 Apr;90(4):465-71. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Optic Disc Cupping | Initial examination | No | |
Secondary | Optic disc size | Inital examination | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05317234 -
Genetic Predisposition in Cerebral Palsy
|
N/A | |
Recruiting |
NCT05576948 -
Natural History of Cerebral Palsy Prospective Study
|
||
Completed |
NCT04119063 -
Evaluating Wearable Robotic Assistance on Gait
|
Early Phase 1 | |
Completed |
NCT03264339 -
The Small Step Program - Early Intervention for Children With High Risk of Developing Cerebral Palsy
|
N/A | |
Completed |
NCT05551364 -
Usability and Effectiveness of the ATLAS2030 Exoskeleton in Children With Cerebral Palsy
|
N/A | |
Completed |
NCT03902886 -
Independent Walking Onset of Children With Cerebral Palsy
|
||
Recruiting |
NCT05571033 -
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
|
N/A | |
Not yet recruiting |
NCT04081675 -
Compliance in Children With Cerebral Palsy Supplied With AFOs
|
||
Completed |
NCT02167022 -
Intense Physiotherapies to Improve Function in Young Children With Cerebral Palsy
|
N/A | |
Completed |
NCT04012125 -
The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy
|
N/A | |
Enrolling by invitation |
NCT05619211 -
Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities
|
Phase 1 | |
Completed |
NCT04489498 -
Comparison of Somatometric Characteristics Between Cerebral Palsy and Normal Children, Cross-sectional, Multi Center Study
|
||
Completed |
NCT03677193 -
Biofeedback-enhanced Interactive Computer-play for Youth With Cerebral Palsy
|
N/A | |
Recruiting |
NCT06450158 -
Robot-assisted Training in Children With CP
|
N/A | |
Completed |
NCT04093180 -
Intensive Neurorehabilitation for Cerebral Palsy
|
N/A | |
Completed |
NCT02909127 -
The Pediatric Eating Assessment Tool
|
||
Not yet recruiting |
NCT06377982 -
Human Umbilical Cord Blood Infusion in Patients With Cerebral Palsy
|
Phase 1 | |
Not yet recruiting |
NCT06007885 -
Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
|
N/A | |
Not yet recruiting |
NCT03183427 -
Corpus Callosum Size in Patients With Pineal Cyst
|
N/A | |
Active, not recruiting |
NCT03078621 -
Bone Marrow-Derived Stem Cell Transplantation for the Treatment of Cerebral Palsy
|
Phase 1/Phase 2 |