Cerebral Palsy Clinical Trial
Official title:
Wavelet Analysis of Surface EMG in Cerebral Palsy
Verified date | January 2009 |
Source | Shriners Hospitals for Children |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
Several methods exist to evaluate motor function in the child with cerebral palsy and are
used to assess the outcome of a clinical intervention. However, these scales are not
directed towards measuring the changes in muscle activity patterns that can result from the
intervention. For example, there are classification scales aimed at measuring motor function
and functional abilities, and indices of gait function. These scores, while providing a way
to quantify function and mechanics, do not directly measure muscle activation
characteristics. Therefore, these tests may be insensitive to how the intervention has
directly affected muscle function, which is usually the focus of the intervention (i.e.
botulinum toxin, functional electrical stimulation, dorsal rhizotomy). Muscle biopsies and
motor evoked potentials can provide information about the muscle activation characteristics,
however, they are invasive and there are concerns about using these techniques on the
pediatric population and/or the practicality of clinical implementation, especially since
they do not provide insight into how the muscle behaves during a functional task. One method
that can be used to provide insight into muscle activity in a non-invasive and clinically
meaningful manner is the use of surface electromyography (sEMG). Surface EMG is typically a
routine part of clinical assessment and the evaluation of motor impairment in CP. However,
the analysis of the data has been limited in most cases to examination of signal amplitude
or differences in muscle onset and offset timing.
The long-term goal of this research is to develop an analysis method for sEMG that can be
used during functional tasks for treatment planning, diagnostic, assessment purposes in CP.
This is to be accomplished through the use of the continuous wavelet transform (CWT). By
developing an assessment method based on muscle activity, it is believed that a clinically
viable measurement tool can be devised that will provide a level of insight into the effects
of an intervention on muscle pathophysiology that is not currently available. The first step
in progressing towards this long-term goal is to determine the variability and range of
expected time-frequency patterns that can be expressed in a given population (i.e., cerebral
palsy) during the execution of a meaningful task (gait), and relate the time-frequency
information back to more standard assessments
Status | Completed |
Enrollment | 32 |
Est. completion date | March 2009 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 7 Years to 12 Years |
Eligibility |
Inclusion Criteria: - A diagnosis of spastic diplegic CP - Must be ambulatory without the use of orthotics - Between a GMFCS Level I and Level III - Between the ages of 7 and 13 years - Cleared by an orthopedic surgeon for risk of hip subluxation or dislocation and cannot have significant scoliosis (curvature > 40 degrees) - Seizure-free or seizure controlled - Has visuoperceptual skills and cognitive/communication skills sufficient to follow multiple step commands and to attend to tasks associated with data collection - Must be greater than 1 year post-surgery to the lower extremities - Must be greater then 6 months botulinum toxin injection - Passive range of motion in lower extremity joints must be greater than 10 degrees of flexion contracture at the hips as measured by the Thomas Test, at least 20 degrees of hip abduction bilaterally, less than 5 degrees of knee flexion contracture, popliteal angle less than 45 degrees, and at least 0 degrees of ankle dorsiflexion with the knee extended while the foot is in varus Exclusion Criteria: - Children who do not meet the inclusion criteria will not be considered for the study. |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Shriners Hospitals for Children | Philadelphia | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
Shriners Hospitals for Children | National Institutes of Health (NIH) |
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