Cerebral Palsy Clinical Trial
Official title:
Classification of Cerebral Palsy Subtypes
This study, conducted at the National Institutes of Health and the Children's National
Medical Center, will evaluate how well different physicians agree in how they classify
cerebral palsy subtypes based on patient examination. Cerebral palsy is divided into several
subtypes, according to the primary underlying muscle abnormality and its distribution and
severity. Classification of these subtypes is important for conducting rehabilitation
research studies on patients with the same type of abnormality. However, doctors do not
always classify cerebral palsy types in the same way. This study will examine methods for
improving agreement among doctors in their classification of cerebral palsy subtypes.
Children between 6 and 18 years of age with cerebral palsy who can voluntarily move their
arms and legs may be eligible for this study. Participants will be examined by at least
three doctors or therapists. The examinations take 30-60 minutes. For the examination, a
doctor or therapist will do the following:
- Observe the patient at rest
- Gently move the patient's arms and legs and then have the patient move his or her arms
and legs
- Check the patient's reflexes
- Observe the patient walking, if the patient is able to walk
Patients will be asked to remain in the clinic for up to 3 hours while researchers discuss
the examination and may be asked to repeat part of the study examination.
Status | Completed |
Enrollment | 115 |
Est. completion date | August 2005 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION CRITERIA: 1. Children 6 to 18 years of age 2. Children must be previously diagnosed with cerebral palsy 3. Children born at any gestational age will be eligible. 4. Lesions must be pre-, peri- or post-natal and acquired before 2 years of age 5. Lesions must be non-progressive 6. Patients must be able to voluntarily move their upper and lower limbs EXCLUSION CRITERIA: 1. Any subject who is pregnant 2. Children with an underlying known genetic or chromosomal disorder 3. Children with clearly identified familial or non-familial syndromes (without known chromosomal or genetic defect) 4. Cerebral lesions acquired after 2 years of age 5. Patients with progressive or neurodegenerative disorders 6. Patients with spinal disorders in the absence of cerebral lesions 7. Patients with sickle cell disease 8. Patients with cerebral lesions caused by emboli associated with congenital cardiac lesions 9. Patients with severe cognitive deficits who cannot follow simple verbal commands 10. Patients incapable of voluntary movement of either upper or lower limbs due to contractures. 11. Patients with prior rhizotomy 12. Patients with prior orthopedic (bone or soft tissue) surgery or serial casting 13. Patients with severe postural abnormalities who cannot maintain supported sitting. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Brashear A, Zafonte R, Corcoran M, Galvez-Jimenez N, Gracies JM, Gordon MF, McAfee A, Ruffing K, Thompson B, Williams M, Lee CH, Turkel C. Inter- and intrarater reliability of the Ashworth Scale and the Disability Assessment Scale in patients with upper-limb poststroke spasticity. Arch Phys Med Rehabil. 2002 Oct;83(10):1349-54. — View Citation
Colver AF, Sethumadhavan T. The term diplegia should be abandoned. Arch Dis Child. 2003 Apr;88(4):286-90. Review. — View Citation
Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW; Task Force on Childhood Motor Disorders. Classification and definition of disorders causing hypertonia in childhood. Pediatrics. 2003 Jan;111(1):e89-97. Review. — View Citation
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