Clinical Trials Logo
  1. Home
  2. Cerebral Arterial Aneurysm
  3. NCT02691416

Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

Carotid Stenosis Clinical Trial

Official title:
Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Carotid Endarterectomy and Cerebral Aneurysmectomy.

Clinical Trial Summary

The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the CEA and Cerebral Aneurysmectomy about antioxidant effect.

Clinical Trial Description

CEA and Cerebral Aneurysmectomy may lead to regional ischemic reperfusion injury.

Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in rats.

As for sevoflurane, some investigation indicated that sevoflurane is able to reduce oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant effect did not found in human minor incision surgeries, furthermore, oxidative stress was raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02691416
Study type Interventional
Source The Third Central Clinical College of Tianjin Medical University
Contact
Status Completed
Phase Phase 4
Start date July 2014
Completion date January 2016
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT03631381 - Retrospective Study of Carotid Surgery in Dijon
Completed NCT05437991 - Ultrasonographic Morphology Assessment of Low-grade Carotid Stenosis N/A
Completed NCT02722720 - Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral N/A
Completed NCT02336958 - Ultrasound Guided Intermediate Cervical Plexus Block and Additional Perivascular Local Anesthetic Infiltration N/A
Completed NCT02630862 - Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization N/A
Completed NCT00536796 - Percentage of Secondary Prevention Patients Treated to Their LDL-C Targets N/A
Recruiting NCT05566301 - Multicentric Study on Clopidogrel Resistance in DAPT for CAS (MULTI-RESCLOSA)
Completed NCT03303534 - Short-Term Endogenous Hydrogen Sulfide Upregulation N/A
Completed NCT01480206 - Overlay of 3D Scans on Live Fluoroscopy for Endovascular Procedures in the Hybrid OR
Recruiting NCT05250349 - TRAnscranial Doppler CErebral Blood Flow and Cognitive IMPAIRment in Heart Failure
Recruiting NCT05845710 - Direct Access Carotid Artery Stenting Using the Neuroguard IEP System (PERFORMANCE III) N/A
Recruiting NCT01732523 - Predictive Value of Neovascularization Within Asymptomatic Carotis Stenosis on CEUS
Completed NCT01315288 - A Randomized Trial of Clinical Decision Making in Asymptomatic Carotid Stenosis N/A
Withdrawn NCT00401921 - A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy Phase 2
Recruiting NCT01273350 - A Prospective, Non-Randomized, Evaluation of Low-Risk Patients Undergoing Carotid Stenting With ANgiomax (Bivalirudin) N/A
Completed NCT03215563 - PET-MRI Imaging in Patients With Acute Neurovascular Syndrome
Completed NCT03215550 - PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
Completed NCT04553549 - Safety and Feasibility of the Infinity Catheter for Radial Access
Completed NCT03596229 - Major Adverse Cardiac Events After Carotid Endarterectomy
Completed NCT04255316 - Modified Method of Eversion Carotid Endarterectomy in Patients With Extensive Atherosclerotic Disease of Carotid Bifurcation N/A