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Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

Carotid Stenosis Clinical Trial

Official title:
Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Carotid Endarterectomy and Cerebral Aneurysmectomy.

Clinical Trial Summary

The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the CEA and Cerebral Aneurysmectomy about antioxidant effect.

Clinical Trial Description

CEA and Cerebral Aneurysmectomy may lead to regional ischemic reperfusion injury.

Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in rats.

As for sevoflurane, some investigation indicated that sevoflurane is able to reduce oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant effect did not found in human minor incision surgeries, furthermore, oxidative stress was raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02691416
Study type Interventional
Source The Third Central Clinical College of Tianjin Medical University
Contact
Status Completed
Phase Phase 4
Start date July 2014
Completion date January 2016
View Details
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