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Antibiotics Against Amyloid Angiopathy — BATMAN  

Cerebral Amyloid Angiopathy Clinical Trial

Official title:
Placebo-controlled, Randomized, Double-blind Study of Minocycline for Sporadic and Hereditary Cerebral Amyloid Angiopathy

Clinical Trial Summary

We will perform a randomized clinical trial with minocycline. Minocycline is an antibiotic of the tetracycline family and known to modulate inflammation, gelatinase activity and angiogenesis, which we know are central mechanisms in CAA-pathology. Our aim is to prove in a randomized clinical trial in a translational setting that minocycline treatment (duration 3 months) can decrease markers of neuroinflammation and the gelatinase pathway in the cerebrospinal fluid (CSF) of persons with D-CAA (n=30) and sporadic-CAA (n=30).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05680389
Study type Interventional
Source Leiden University Medical Center
Contact Sabine Voigt, BSc
Phone +31715261825
Email BATMAN@lumc.nl
Status Recruiting
Phase Phase 1/Phase 2
Start date December 2, 2020
Completion date December 2, 2023
View Details
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