Pain Clinical Trial
Official title:
Potential Influences of Respiration Patterns on Experimental Pain Sensitization
The goal of this clinical trial is to investigate the effect of breathing on the processing of experimental pain in healthy participants. The main questions are: 1. Does breathing rate influence the spatial extent of thermally induced secondary hyperalgesia, a proxy of central sensitization? 2. Does resonance frequency breathing influence the autonomic nervous system, compared to baseline and compared to paced breathing at a natural frequency? 3. Is spinal excitability, measured using the magnitude of the nociception withdrawal reflex (NWR), affected by resonance frequency breathing, compared to paced breathing at a natural frequency? Participants: - will receive heat stimuli - 's skin's sensitivity will be tested using quantitative sensory testing tools. - will receive various instructions on the speed of their breathing - 's heart rate, respiratory rate and sweat response will be measured - will fill in questionnaires Researchers will compare the spatial extent of sensitivity resulting from application of heat stimuli during paced resonance frequency breathing compared to paced breathing at a natural frequency to see if the breathing rhythm influences central sensitization processes.
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