Central Obesity Clinical Trial
Official title:
The Association Between Microbiota, Endotoxaemia and the Host Obesity/ Insulin Resistance (MiPOOP Study)
The objectives of this study are to examine the effects of ethnicity, central obesity and dietary components, on the human gut microbiome. The investigators hypothesize that these factors have an influence on the composition of the gut microbiome. Healthy subjects (n=35) provided stool samples for gut microbiome profiling using 16S rRNA sequencing and completed a dietary questionnaire. The serum samples were assayed for a panel of inflammatory cytokines. Their associations with central obesity were examined.
Introduction: Perturbance in the composition of human gut microbiota has been associated with
metabolic disorders such as obesity, diabetes mellitus and insulin resistance. The objectives
of this study are to examine the effects of ethnicity, central obesity and dietary
components, on the human gut microbiome. The investigators hypothesize that these factors
have an influence on the composition of the gut microbiome.
Methods: Subjects of Chinese (n=14), Malay (n=10) or Indian (n=11) ancestry, median age 39
(range:22-70 years old), were enrolled. The subjects provided stool samples for gut
microbiome profiling using 16S rRNA sequencing and completed a dietary questionnaire. The
serum samples were assayed for a panel of biomarkers (Interleukin-6, tumour necrosis factor
alpha, adiponectin, cleaved cytokeratin 18, lipopolysaccharide binding protein and limulus
amebocyte lysate). Central obesity was defined by waist circumference cut-offs in Asians.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02375113 -
Soy as an Innovative Dietary Component in Abdominal Obesity Management Amongst Peri- and Early Menopausal Women
|
N/A | |
Withdrawn |
NCT04545320 -
Effectiveness of High-intensity Interval Training (HIIT) Versus Moderate-intensity Continuous Training (MICT) in Reducing Visceral Fat in Adults With Central Obesity
|
N/A | |
Completed |
NCT04807959 -
Evaluation of the Effectiveness of a Comprehensive Visceral Adiposity-Focused Anti-Obesity Program
|
||
Recruiting |
NCT05833009 -
Acupuncture Treatment for Schizophrenia-related Central Obesity
|
N/A | |
Completed |
NCT01881373 -
Children's Healthy Living Community Randomized Trial
|
N/A | |
Recruiting |
NCT05121844 -
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
|
N/A | |
Recruiting |
NCT05874635 -
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
|
N/A | |
Withdrawn |
NCT03120390 -
Physical Activity in Reducing Metabolic Dysregulation (MetD) in Obese Latina Breast Cancer Survivors
|
N/A | |
Completed |
NCT04152213 -
The Effects of Low Glycemic Index (GI) Diet on Cardiometabolic Outcomes Among Obese Chinese Adults
|
N/A | |
Completed |
NCT04761081 -
Is Physical Activity, Obesity, and Ethnicity Associated With the Tethering and Migration of Pro-inflammatory Monocytes?
|
||
Completed |
NCT02987595 -
Effects of Lignan-rich Diet on Cardiometabolic Risk Factors
|
N/A | |
Not yet recruiting |
NCT03552237 -
Effect of Dietary Fiber Supplement on the Intestinal Microbiota Among Schizophrenia Patients
|
N/A | |
Recruiting |
NCT06024018 -
Effect of High Intensity Electromagnetic Body Shaping on Profile of Metabolism in Obese Men
|
N/A | |
Withdrawn |
NCT03091842 -
Exercise Intervention in Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer
|
N/A | |
Completed |
NCT02320760 -
Physical Activity on Prescription in Overweight Older Adults
|
N/A | |
Active, not recruiting |
NCT03912272 -
12-Month Once-a-week HIIT Improves Body Adiposity and Liver Fat
|
N/A | |
Completed |
NCT02010060 -
Aerobic Training and Non-Exercise Physical Activity
|
N/A | |
Completed |
NCT03815253 -
Electro-acupuncture for Central Obesity
|
N/A | |
Completed |
NCT01445730 -
Fructose Consumption and Metabolic Dysregulation
|
N/A | |
Completed |
NCT03279432 -
Vitamin D-related Genes and Metabolic Disorders
|
N/A |