Central Obesity Clinical Trial
Official title:
The Association Between Microbiota, Endotoxaemia and the Host Obesity/ Insulin Resistance (MiPOOP Study)
The objectives of this study are to examine the effects of ethnicity, central obesity and dietary components, on the human gut microbiome. The investigators hypothesize that these factors have an influence on the composition of the gut microbiome. Healthy subjects (n=35) provided stool samples for gut microbiome profiling using 16S rRNA sequencing and completed a dietary questionnaire. The serum samples were assayed for a panel of inflammatory cytokines. Their associations with central obesity were examined.
Introduction: Perturbance in the composition of human gut microbiota has been associated with
metabolic disorders such as obesity, diabetes mellitus and insulin resistance. The objectives
of this study are to examine the effects of ethnicity, central obesity and dietary
components, on the human gut microbiome. The investigators hypothesize that these factors
have an influence on the composition of the gut microbiome.
Methods: Subjects of Chinese (n=14), Malay (n=10) or Indian (n=11) ancestry, median age 39
(range:22-70 years old), were enrolled. The subjects provided stool samples for gut
microbiome profiling using 16S rRNA sequencing and completed a dietary questionnaire. The
serum samples were assayed for a panel of biomarkers (Interleukin-6, tumour necrosis factor
alpha, adiponectin, cleaved cytokeratin 18, lipopolysaccharide binding protein and limulus
amebocyte lysate). Central obesity was defined by waist circumference cut-offs in Asians.
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