Schizophrenia Clinical Trial
Official title:
The Effect of Dietary Fiber Supplement on the Intestinal Microbiota Among Schizophrenia Patients With Central Obesity: a Pilot Study
Background There has been much interest in the relationship between the types of gut
microbiota and the development of obesity in recent years. It has been reported that the
proportions of Firmicutes and Bacteroidetes differ between obese and normal weight human
subjects. Human intestinal microbiota compositions have been found to be associated with
long-term dietary habits and lifestyle. However, an increasing number of researches show that
intestinal microbiota composition may be affected after short-term diet intervention.
Importantly, obesity and metabolic problems play important roles in morbidity and mortality
of schizophrenia patients. Human intestinal microbiota compositions related with obesity may
impact the heath of this population. Therefore, we searched current advances about the
connection of obesity, intestinal microbiota compositions, and diet in schizophrenia to
conduct a clinical research focus on the effect of high fiber diet on the intestinal
microbiota of schizophrenia patients with central obesity.
Method We will investigate in a 4-week intervention whether consumption of dietary fiber
supplement(Inulin) affect the microbiota composition in schizophrenia inpatients with central
obesity. Fecal samples from participants before and after the intervention will be processed
for the microbiota analysis.
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