Central Blood Pressure in Diabetic Hypertensive Clinical Trial
Official title:
The Effect of Central Blood Pressure on Clinical Outcome in Diabetic Hypertensive Patients in Assiut University Hospitals
In recent decades, some observational studies suggest that peripheral BP measured by brachial artery may not necessarily represent BP measured in the aortic artery which is known as central BP .In addition, some clinical trials also revealed that despite with comparable peripheral BP, patients with high central BP had significantly higher cardiovascular risk compared with those with low central BP indicating that central BP might be an independent predictor for CVD
Diabetes mellitus (DM) is amajor risk factor for cardiovascular and renal diseases[1] .It is
known about two thirds of diabetic patients died from these complication .Numerous
epidemiological studies demonstrate that DM is commonly accompanied with hypertension and
patients with diabetes and hypertension have higher renal and cardiovascular risks compared
with those with either hypertension or diabetes. Therefore, better evaluating and managing BP
in diabetic patients with hypertension is clinically relevant.
Hypertension also is a major risk factor for cardiovascular diseases (CVD) and all-cause
mortality . Numerous randomized controlled trials using antihypertensive drugs and
meta-analysis demonstrate that lowering peripheral blood pressure (BP) is beneficial for
reducing cardiovascular and renal events.
In recent decades, some observational studies suggest that peripheral BP measured by brachial
artery may not necessarily represent BP measured in the aortic artery which is known as
central BP.
In addition, some clinical trials also revealed that despite with comparable peripheral BP,
patients with high central BP had significantly higher cardiovascular risk compared with
those with low central BP indicating that central BP might be an independent predictor for
CVD
;