Gluten Challenge in Celiac Disease

Status Recruiting

Clinical Trial Summary

Up till 30 participants with celiac disease on a glutenfree diet are asked to consume gluten containing cookies or bread for 3 days.

Questionnaires and sampling of blood is done before, during and after.

Clinical Trial Description

Before and 6 days after start of gluten challenge, blood samples will be collected and analysed by using HLA-tetramers to identify and purify CD4+ gluten-specific T cells by flow cytometry. T cells will undergo transcriptome analysis to get an insight in signalling of antigen-specific cells. Other cell populations like CD8+ T cells and γδ T cells will also be analyzed by flow cytometry. ;

Study Design

Related Conditions & MeSH terms

Celiac Disease

Clinical Trial Details

NCT number	NCT02464150
Study type	Interventional
Source	Oslo University Hospital
Contact	Stephanie Zühlke, MD
Phone	23074224
Email	stephanie.zuhlke@medisin.uio.no
Status	Recruiting
Phase	N/A
Start date	April 1, 2017
Completion date	August 2028

View Details

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