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Celiac Disease clinical trials

View clinical trials related to Celiac Disease.

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NCT ID: NCT03775499 Recruiting - Celiac Disease Clinical Trials

Probiotic BL NCC 2705 and Gluten Sensitivity

Start date: October 10, 2018
Phase: N/A
Study type: Interventional

The aim of the study is to confirm/prove safety of the probiotic and production of serpin in humans.

NCT ID: NCT03771443 Not yet recruiting - Gluten Sensitivity Clinical Trials

Assessment of the Effect of Gluten Free Toothpaste on the Ulcerative Events in Children With Celiac Disease

Start date: January 2019
Phase: Phase 3
Study type: Interventional

Celiac disease (CD) is the most common genetically based food intolerance in the world, with a prevalence among approximately 1% of the general population (Guandalini & Assiri, 2014). CD is a frequent disorder among Egyptian children, both in the general population and in at-risk groups(Abu-Zekry et al., 2008). It is estimated that the incidence of CD is 3 to13 cases per1000, with a higher prevalence among first-degree relatives of patients with CD.Lifelong adherence to a strict gluten free diet (GFD) remains the only available treatment for patients with CD and typically results in a complete return to health. Nevertheless, gluten is not found only in diet, Gluten is commonly used as a binder in products like medication, cosmetics, oral and skin care, and even children's toys. Gluten is found also in toothpastes and other oral health products and it can be swallowed by mistake and initiate immune response(Anon, n.d.). Unfortunately, there is no gluten free toothpaste available in the Egyptian market and it is very expensive if we bought it from Europe or USA. The tube will cost nearly 10 dolars .As a result, the production and availability of gluten free toothpaste in Egypt has become mandatory.

NCT ID: NCT03763487 Recruiting - Celiac Disease Clinical Trials

The Aim of This Project is to Verify Whether a Depletion of B Cell Memory Subpopulation ("Marginal-zone-like") CD19 + IgD + CD27 + and CD19 + IgM + CD27 + is a Useful Indicator of Hyposplenism in Patients With Celiac Disease

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

This project is expected to confirm the hypothesis that hyposplenism in patients with celiac disease is not conditioned by a selective memory deficiency of B lymphocytes. Other objectives of project are: - determination of gliadin 33-mer in faecal and urine as indicators patient´s adherence to gluten-free diet - determination of citrulline in plasma as an indicator of the overall functional capacity enterocytes

NCT ID: NCT03738475 Recruiting - Celiac Disease Clinical Trials

Study of the Safety, Pharmacodynamics, Efficacy, and PK of TIMP-GLIA in Subjects With Celiac Disease

Start date: January 4, 2019
Phase: Phase 2
Study type: Interventional

Subjects enrolled in this study will be evaluated for immune responses and histological changes in the small bowel following 2 doses of TIMP-GLIA or placebo and a 14-day oral gluten challenge.

NCT ID: NCT03731806 Not yet recruiting - Celiac Disease Clinical Trials

Capsule Endoscopy in Newly Diagnosed Patients of Celiac Disease

Start date: December 2018
Phase:
Study type: Observational

Celiac Disease is an autoimmune disorder that affects approximately 1% of the world's population 1. The diagnosis of CD requires clinical, histopathological and serological factors 2. Since upper gastrointestinal endoscopy allows only visualization of the small bowel up to the second part of duodenum therefore this study was designed to determine involvement of different segments of small bowel using endoscopic scale by Bonatto MW et al 3 in newly diagnosed patients of celiac disease.

NCT ID: NCT03707730 Not yet recruiting - Celiac Disease Clinical Trials

A Randomized, Double-Blind, Placebo Controlled, Crossover Trial to Evaluate Safety and Efficacy of AGY in Celiac Disease

AGY-010
Start date: December 2018
Phase: Phase 2
Study type: Interventional

To assess the efficacy and safety of AGY vs placebo when administered to individuals age 10 to 65 years with medically proven CD and on a gluten free diet

NCT ID: NCT03678935 Active, not recruiting - Clinical trials for Irritable Bowel Syndrome

Effect of FODMAP Restriction on Persistent GI-symptoms in Coeliac Patients

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

The first aim of the study is to investigate the prevalence of persistent gastrointestinal symptoms and compliance with gluten-free diet and the intake of FODMAP in adult celiac patients. A web-based survey wil be performed and thereafter a randomized controlled trial to test the effect of a FODMAP reduction in patients with celiac disease with irritable bowel-like symptoms.

NCT ID: NCT03663309 Not yet recruiting - Clinical trials for Celiac Disease in Children

Assessment of Adherence to Gluten Free Diet in Children and Adolescents by Detection of Gluten in Faecal Samples.

Start date: September 2018
Phase:
Study type: Observational

To assess the adherence to gluten free diet by measuring faecal and urinary gluten immunogenic peptides (GIP). This will provide an objective measure for adherence.

NCT ID: NCT03644602 Completed - Clinical trials for Irritable Bowel Syndrome

Low FODMAPs Diet in Gastrointestinal Disorders

FODMAPs
Start date: July 2016
Phase: N/A
Study type: Interventional

Recent studies have shown that FODMAPs (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) free diet is efficient in subjects with Irritable Bowel Syndrome (IBS). Patients with Inflammatory Bowel Diseases (IBD) and celiac disease (CD) can experience functional gastrointestinal symptoms not related to inflammation, but data about the use of low FODMAPs diet in these settings are still scarce. The aim of the present study was to evaluate the usefulness of a low FODMAPs diet in patients with IBS, non-active IBD and CD on strict gluten-free diet (GFD). A low FODMAPs diet could be a valid option to contrast abdominal symptoms in patients with IBS, non-active IBD and CD on GFD, thus improving the quality of life and the social relations.

NCT ID: NCT03644069 Recruiting - Celiac Disease Clinical Trials

A Study of the Safety, Efficacy and Tolerability of Nexvax-2 in Patients With Celiac Disease (CeD)

Start date: August 6, 2018
Phase: Phase 2
Study type: Interventional

A randomized, double-blind, placebo-controlled clinical study in human leukocyte antigen (HLA)-DQ 2.5+ adults with celiac disease (CeD).