Cataracts Clinical Trial
Official title:
Clinical Research of Femtosecond Laser-Assisted Cataract Surgery: Randomized Clinical Trial
Since femtosecond laser was approved for cataract surgery by FDA in 2010, femtosecond laser
assisted cataract surgery (FLACS) has demonstrated high precision of capsulotomy, reduced
phacoemulsification power and time, and comparable refractive outcome in clinic.
It is still unknown whether there are toxic substances produced due to photochemical or
high-energy physical effect of femtosecond laser during FLACS.
Phacoemulsification is one of the main surgical procedures for cataract surgery owing to the
advantages of small incisions and rapid recovery. However, the surgical outcome of
phacoemulsification can be negatively affected due to the problem of accuracy and
repeatability for capsulorhexis, and the corneal endothelial cell damage by ultrasound
energy.To overcome those problems from the phacoemulsification, femtosecond laser-assisted
cataract surgery (FLACS) had been used in the past few years and showed unique advantages.
The purpose of this study is to investigate the preliminary clinical outcomes of femtosecond
laser-assisted cataract surgery.This prospective comparative study enrolled consecutive
patients,will be randomly assigned to trial group underwent FLACS and control group
underwent conventional cataract surgery.
The phacoemulsification time, energy, and complications during operation were recorded.
The anterior capsule and aqueous humor were collected. Morphology of the cutting edge and
cells of anterior capsule was assessed by light microscopy. The proteins in the aqueous
humor were identified by mass spectrometry . Electrolyte in the aqueous humor was detected
by a chemistry analyzer. Postoperative refraction at 1 day, 1 week, 1 and 3 months, the
capsulorhexis size and corneal endothelial density at 1 and 3 months were also measured.
;
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT06005675 -
User Acceptability Evaluation of Pseudophakic Patients Previously Implanted With the TECNIS Odyssey IOL
|
||
| Active, not recruiting |
NCT01382641 -
Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery
|
Phase 4 | |
| Completed |
NCT01382823 -
Laser Cataract Surgery With the Femtosecond Laser Technology
|
Phase 4 | |
| Completed |
NCT05991960 -
Evaluation of Real-World Data on the Performance of the TECNIS Odyssey™ IOL
|
||
| Active, not recruiting |
NCT05574959 -
Clinical Investigation of the TECNIS® Next-Generation Intraocular Lens, Model DEN00V
|
N/A | |
| Completed |
NCT01279031 -
Randomized Comparison of the Abbott WHITESTAR Signature System With Ellips Tranversal Ultrasound vs. the Alcon Infiniti With the Ozil Torsional Handpiece in Phacoemulsification: A Contralaterally-Controlled Trial
|
Phase 4 | |
| Completed |
NCT01061463 -
Occupational Cataracts and Lens Opacities in Interventional Cardiology : the O'CLOC Study
|
N/A | |
| Completed |
NCT00999492 -
Selection of Aspheric Diffractive Multifocal Intraocular Lens (IOLS) Based on Corneal Wavefront
|
Phase 4 | |
| Completed |
NCT01021761 -
A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification
|
Phase 4 | |
| Completed |
NCT01001806 -
A Comparison of Peak Aqueous Penetration of Acuvail (Ketorolac 0.45%), Xibrom (Bromfenac 0.09%), and Nevanac (Nepafenac 0.1%)in Patients Undergoing Phacoemulsification
|
Phase 4 | |
| Completed |
NCT00542581 -
Acrysof Toric SN60T3corneal Astigmatism Between 0.75 and 1.00 D.
|
N/A | |
| Completed |
NCT03708367 -
A Post-Market Evaluation of LipiFlow Treatment in Cataract Surgery Practice
|
N/A | |
| Completed |
NCT05575063 -
Clinical Investigation of Healon EndoCoat Ophthalmic Viscosurgical Device (OVD)
|
N/A | |
| Recruiting |
NCT05531292 -
PROOF-OF-CONCEPT STUDY FOR NEW INTRAOCULAR LENS, MODEL C0002
|
N/A | |
| Completed |
NCT05058274 -
Clinical Results of a Monofocal Aspheric Bitoric Intraocular Lens With Plate Haptics in Hyperopic Eyes (HIPER-AT-TORBI)
|
||
| Completed |
NCT05053399 -
Evaluation of the TECNIS Symfony® Toric Intraocular Lens
|
N/A | |
| Recruiting |
NCT02639845 -
Eye Drop Application Monitor, Pilot Study
|
N/A | |
| Completed |
NCT01684007 -
A Clinical Outcome Study of Two Multifocal Intraocular Lenses (IOL) in Cataract Patients
|
N/A | |
| Completed |
NCT00827073 -
Comparison of Tetracaine 0.5% and Lidocaine 2% Jelly for Topical Phacoemulsification Cataract Surgery
|
N/A | |
| Completed |
NCT00405730 -
Nepafenac 0.1% Eye Drops, Suspension Compared to Ketorolac Trometamol 0.5% Eye Drops, Solution and Placebo
|
Phase 3 |